| Literature DB >> 15125646 |
Biao Xi1, Fangxia Guan, David S Lawrence.
Abstract
Nonsense mutations are associated with a host of genetic disorders. The protein products encoded by genes containing these mutations are either truncated or completely missing. Recently, members of the aminoglycoside family of antibiotics have been found to induce the ribosome to read past these inappropriately inserted stop codons, albeit at extremely modest efficiencies. We report herein a strategy that enhances the production of functional proteins from the corresponding mutated genes.Entities:
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Year: 2004 PMID： 15125646 DOI： 10.1021/ja0318939
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419