| Literature DB >> 15117457 |
Takaichi Hamano1, Pathom Sawanpanyalert, Hideki Yanai, Surachai Piyaworawong, Takashi Hara, Sompong Sapsutthipas, Jurairat Phromjai, Shudo Yamazaki, Naoki Yamamoto, Paijit Warachit, Mitsuo Honda, Kazuhiro Matsuo.
Abstract
A molecular epidemiological study of the gag p17 and env-V3 regions on HIV-infected drug users and blood donors was carried out in northern Thailand from 1998 through 2002 to determine the predominant subtype and consensus sequence (CS) for circulating HIV-1 strains. CRF01_AE was concluded to be a predominant strain and the nucleotide CSs in gag p17 and env-V3 showed only 1.26% and no difference from CS in the Los Alamos database, respectively. Our env-V3 CS was identical to the previously published CSs, suggesting that the CS was very conserved from 1990 through 2002 in Thailand. Gag p17 and env-V3 nucleotide sequences of seroconvertors in our subjects were quite similar to the CS and conserved for at least 9 and 6 years postinfection, respectively. These results suggest that the CS approach to the HIV-1 antigen design could overcome HIV diversity and help us develop an effective HIV/AIDS vaccine.Entities:
Mesh：
Substances：
Year: 2004 PMID： 15117457 DOI： 10.1089/088922204322996572
Source DB: PubMed Journal: AIDS Res Hum Retroviruses ISSN： 0889-2229 Impact factor: 2.205