Literature DB >> 15113522

Impact of the CSM advice on thioridazine on general practitioner prescribing behaviour in Leeds: time series analysis.

Nat M J Wright1, Alison J Roberts, Victoria L Allgar, Charlotte N E Tompkins, Darren C Greenwood, Gillian Laurence.   

Abstract

In December 2000, the Committee for Safety of Medicines (CSM) advised that thioridazine may prolong QT intervals risking arrhythmias. We investigated the impact on general practitioner prescribing of thioridazine using a time series analysis. Numbers of items and costs of antipsychotics and benzodiazepines prescribed in Leeds from May 1999 until April 2002 were collated. Post-advice, thioridazine prescriptions dropped by 810 items per month (95% confidence interval = 420 to 1200, P < 0.001) but others increased slightly in response. Costs mimicked these changes. Fresh criteria are proposed for appraising the quality of evidence needed to inform future urgent facsimile transmissions.

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Year:  2004        PMID： 15113522      PMCID： PMC1266173     

Source DB:  PubMed          Journal:  Br J Gen Pract        ISSN： 0960-1643            Impact factor:   5.386


  11 in total

1.  Cluster randomized trials in general (family) practice research.

Authors:  M J Campbell
Journal:  Stat Methods Med Res       Date:  2000-04       Impact factor: 3.021

2.  Impact of NHS direct on demand for immediate care: observational study.

Authors:  J Munro; J Nicholl; A O'Cathain; E Knowles
Journal:  BMJ       Date:  2000-07-15

3.  Sudden cardiac death and antipsychotic drugs: do we know enough?

Authors:  C A Zarate; J Patel
Journal:  Arch Gen Psychiatry       Date:  2001-12

4.  Removal of thioridazine from primary care formulary will result in prescribing vacuum.

Authors:  N Wright
Journal:  BMJ       Date:  2001-09-22

5.  The effect of GP telephone triage on numbers seeking same-day appointments.

Authors:  Moyez Jiwa; Nigel Mathers; Mike Campbell
Journal:  Br J Gen Pract       Date:  2002-05       Impact factor: 5.386

6.  Impact of the CSM advice on thioridazine on general practitioner prescribing behaviour in Leeds: time series analysis.

Authors:  Nat M J Wright; Alison J Roberts; Victoria L Allgar; Charlotte N E Tompkins; Darren C Greenwood; Gillian Laurence
Journal:  Br J Gen Pract       Date:  2004-05       Impact factor: 5.386

7.  UK "pill scare" led to abortion increase.

Authors:  S Ramsay
Journal:  Lancet       Date:  1996-04-20       Impact factor: 79.321

8.  Antipsychotics and the risk of sudden cardiac death.

Authors:  W A Ray; S Meredith; P B Thapa; K G Meador; K Hall; K T Murray
Journal:  Arch Gen Psychiatry       Date:  2001-12

9.  Long-term treatment with antipsychotic drugs in conventional doses prolonged QTc dispersion, but did not increase ventricular tachyarrhythmias in patients with schizophrenia in the absence of cardiac disease.

Authors:  H Kitayama; K Kiuchi; J Nejima; T Katoh; T Takano; H Hayakawa
Journal:  Eur J Clin Pharmacol       Date:  1999-06       Impact factor: 2.953

Review 10.  QT-interval prolongation by non-cardiac drugs: lessons to be learned from recent experience.

Authors:  F De Ponti; E Poluzzi; N Montanaro
Journal:  Eur J Clin Pharmacol       Date:  2000-04       Impact factor: 2.953
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  5 in total

1.  Impact of the CSM advice on thioridazine on general practitioner prescribing behaviour in Leeds: time series analysis.

Authors:  Nat M J Wright; Alison J Roberts; Victoria L Allgar; Charlotte N E Tompkins; Darren C Greenwood; Gillian Laurence
Journal:  Br J Gen Pract       Date:  2004-05       Impact factor: 5.386

2.  CSM thioridazine advice.

Authors:  Paul Driscoll
Journal:  Br J Gen Pract       Date:  2004-08       Impact factor: 5.386

3.  CSM thioridazine advice.

Authors:  Michael Wilcock
Journal:  Br J Gen Pract       Date:  2004-08       Impact factor: 5.386

Review 4.  What is the effectiveness of printed educational materials on primary care physician knowledge, behaviour, and patient outcomes: a systematic review and meta-analyses.

Authors:  Agnes Grudniewicz; Ryan Kealy; Reitze N Rodseth; Jemila Hamid; David Rudoler; Sharon E Straus
Journal:  Implement Sci       Date:  2015-12-01       Impact factor: 7.327

5.  Measuring the impact of medicines regulatory interventions - Systematic review and methodological considerations.

Authors:  Thomas Goedecke; Daniel R Morales; Alexandra Pacurariu; Xavier Kurz
Journal:  Br J Clin Pharmacol       Date:  2017-12-20       Impact factor: 4.335
  5 in total

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