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Literature DB >> 15105146

Inhibitory activity of alkoxyalkyl and alkyl esters of cidofovir and cyclic cidofovir against orthopoxvirus replication in vitro.

Kathy A Keith¹, William B Wan, Stephanie L Ciesla, James R Beadle, Karl Y Hostetler, Earl R Kern.

Abstract

A new series of ether lipid esters of cidofovir (CDV) were evaluated against vaccinia and cowpox viruses. Activity was dependent on number of atoms in the alkyl or alkoxyalkyl chain, the linker moiety, and the presence of a double bond in the alkoxyalkyl chains linked to the phosphonate moiety of CDV.

Entities: Chemical

Mesh：

Substances：

Year: 2004 PMID： 15105146 PMCID： PMC400568 DOI： 10.1128/AAC.48.5.1869-1871.2004

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

13 in total

1. Antivaccinia activities of acyclic nucleoside phosphonate derivatives in epithelial cells and organotypic cultures.

Authors: R Snoeck; A Holý; C Dewolf-Peeters; J Van Den Oord; E De Clercq; G Andrei
Journal: Antimicrob Agents Chemother Date: 2002-11 Impact factor: 5.191

Review 2. Smallpox and smallpox vaccination: neurological implications.

Authors: John Booss; Larry E Davis
Journal: Neurology Date: 2003-04-22 Impact factor: 9.910

3. Cidofovir protects mice against lethal aerosol or intranasal cowpox virus challenge.

Authors: M Bray; M Martinez; D F Smee; D Kefauver; E Thompson; J W Huggins
Journal: J Infect Dis Date: 2000-01 Impact factor: 5.226

4. Enhanced inhibition of orthopoxvirus replication in vitro by alkoxyalkyl esters of cidofovir and cyclic cidofovir.

Authors: Earl R Kern; Caroll Hartline; Emma Harden; Kathy Keith; Natalie Rodriguez; James R Beadle; Karl Y Hostetler
Journal: Antimicrob Agents Chemother Date: 2002-04 Impact factor: 5.191

Review 5. A review of compounds exhibiting anti-orthopoxvirus activity in animal models.

Authors: Donald F Smee; Robert W Sidwell
Journal: Antiviral Res Date: 2003-01 Impact factor: 5.970

6. Alkoxyalkyl esters of cidofovir and cyclic cidofovir exhibit multiple-log enhancement of antiviral activity against cytomegalovirus and herpesvirus replication in vitro.

Authors: James R Beadle; Caroll Hartline; Kathy A Aldern; Natalie Rodriguez; Emma Harden; Earl R Kern; Karl Y Hostetler
Journal: Antimicrob Agents Chemother Date: 2002-08 Impact factor: 5.191

Review 7. Pathogenesis and potential antiviral therapy of complications of smallpox vaccination.

Authors: Mike Bray
Journal: Antiviral Res Date: 2003-04 Impact factor: 5.970

8. Oral treatment of cowpox and vaccinia virus infections in mice with ether lipid esters of cidofovir.

Authors: Debra C Quenelle; Deborah J Collins; W Brad Wan; James R Beadle; Karl Y Hostetler; Earl R Kern
Journal: Antimicrob Agents Chemother Date: 2004-02 Impact factor: 5.191

9. Evaluation of nucleoside phosphonates and their analogs and prodrugs for inhibition of orthopoxvirus replication.

Authors: Kathy A Keith; Michael J M Hitchcock; William A Lee; Antonin Holý; Earl R Kern
Journal: Antimicrob Agents Chemother Date: 2003-07 Impact factor: 5.191

10. Potential antiviral therapeutics for smallpox, monkeypox and other orthopoxvirus infections.

Authors: Robert O Baker; Mike Bray; John W Huggins
Journal: Antiviral Res Date: 2003-01 Impact factor: 10.103

24 in total

1. Efficacy of CMX001 against herpes simplex virus infections in mice and correlations with drug distribution studies.

Authors: Debra C Quenelle; Bernhardt Lampert; Deborah J Collins; Terri L Rice; George R Painter; Earl R Kern
Journal: J Infect Dis Date: 2010-10-05 Impact factor: 5.226

Review 2. The search for new therapies for human cytomegalovirus infections.

Authors: Mark N Prichard; Earl R Kern
Journal: Virus Res Date: 2010-11-21 Impact factor: 3.303

Review 3. Prodrugs of phosphonates and phosphates: crossing the membrane barrier.

Authors: Andrew J Wiemer; David F Wiemer
Journal: Top Curr Chem Date: 2015

Review 4. Phosphonate prodrugs: an overview and recent advances.

Authors: Kenneth M Heidel; Cynthia S Dowd
Journal: Future Med Chem Date: 2019-07 Impact factor: 3.808

5. Advances in the Development of Therapeutics for Cytomegalovirus Infections.

Authors: Edward Acosta; Terry Bowlin; Jennifer Brooks; Lillian Chiang; Islam Hussein; David Kimberlin; Lawrence M Kauvar; Randi Leavitt; Mark Prichard; Richard Whitley
Journal: J Infect Dis Date: 2020-03-05 Impact factor: 5.226

6. Activities of alkoxyalkyl esters of cidofovir (CDV), cyclic CDV, and (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine against orthopoxviruses in cell monolayers and in organotypic cultures.

Authors: Ilya Lebeau; Graciela Andrei; Fabiana Dal Pozzo; James R Beadle; Karl Y Hostetler; Erik De Clercq; Joost van den Oord; Robert Snoeck
Journal: Antimicrob Agents Chemother Date: 2006-07 Impact factor: 5.191

7. Inhibition of herpesvirus replication by hexadecyloxypropyl esters of purine- and pyrimidine-based phosphonomethoxyethyl nucleoside phosphonates.

Authors: Mark N Prichard; Caroll B Hartline; Emma A Harden; Shannon L Daily; James R Beadle; Nadejda Valiaeva; Earl R Kern; Karl Y Hostetler
Journal: Antimicrob Agents Chemother Date: 2008-10-13 Impact factor: 5.191

8. Pharmacodynamics of cidofovir for vaccinia virus infection in an in vitro hollow-fiber infection model system.

Authors: James J McSharry; Mark R Deziel; Kris Zager; Qingmei Weng; George L Drusano
Journal: Antimicrob Agents Chemother Date: 2008-10-13 Impact factor: 5.191

9. Using biomarkers to stage disease progression in a lethal mousepox model treated with CMX001.

Authors: Scott Parker; Jill Schriewer; Christina Oberle; Alice Robertson; Randall Lanier; George Painter; R Mark Buller
Journal: Antivir Ther Date: 2008

10. Antischistosomal activity of hexadecyloxypropyl cyclic 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine and other alkoxyalkyl esters of acyclic nucleoside phosphonates assessed by schistosome worm killing in vitro.

Authors: Sanaa S Botros; Samia William; James R Beadle; Nadejda Valiaeva; Karl Y Hostetler
Journal: Antimicrob Agents Chemother Date: 2009-08-24 Impact factor: 5.191