Literature DB >> 19704122

Antischistosomal activity of hexadecyloxypropyl cyclic 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine and other alkoxyalkyl esters of acyclic nucleoside phosphonates assessed by schistosome worm killing in vitro.

Sanaa S Botros1, Samia William, James R Beadle, Nadejda Valiaeva, Karl Y Hostetler.   

Abstract

9-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl]adenine [(S)-HPMPA] has been reported to have antischistosomal activity. Ether lipid esters of (S)-HPMPA and cidofovir (CDV) have greatly increased activities in antiviral assays and in lethal animal models of poxvirus diseases. To see if ether lipid esters of CDV and (S)-HPMPA enhance antischistosomal activity, we tested their alkoxyalkyl esters using Schistosoma mansoni worm killing in vitro. Hexadecyloxypropyl (HDP)-cyclic-(S)-HPMPA and HDP-cyclic-CDV exhibited significant in vitro antischistosomal activities and may offer promise alone or in combination with praziquantel.

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Year:  2009        PMID： 19704122      PMCID： PMC2786359          DOI： 10.1128/AAC.00840-09

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  33 in total

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Journal:  Parasitol Int       Date:  2004-06       Impact factor: 2.230

Review 2.  Towards control of schistosomiasis in sub-Saharan Africa.

Authors:  V R Southgate; D Rollinson; L A Tchuem Tchuenté; P Hagan
Journal:  J Helminthol       Date:  2005-09       Impact factor: 2.170

3.  Advances in the discovery and development of trematocidal drugs.

Authors:  Jennifer Keiser; Jürg Utzinger
Journal:  Expert Opin Drug Discov       Date:  2007-10       Impact factor: 6.098

4.  Comparison of the antiviral activities of alkoxyalkyl and alkyl esters of cidofovir against human and murine cytomegalovirus replication in vitro.

Authors:  William B Wan; James R Beadle; Caroll Hartline; Earl R Kern; Stephanie L Ciesla; Nadejda Valiaeva; Karl Y Hostetler
Journal:  Antimicrob Agents Chemother       Date:  2005-02       Impact factor: 5.191

5.  The octadecyloxyethyl ester of (S)-9-[3-hydroxy-2-(phosphonomethoxy) propyl]adenine is a potent and selective inhibitor of hepatitis C virus replication in genotype 1A, 1B, and 2A replicons.

Authors:  David L Wyles; Kelly A Kaihara; Brent E Korba; Robert T Schooley; James R Beadle; Karl Y Hostetler
Journal:  Antimicrob Agents Chemother       Date:  2009-03-16       Impact factor: 5.191

6.  Activity of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine against Schistosomiasis mansoni in mice.

Authors:  Sanaa Botros; Samia William; Olfat Hammam; Zdenĕk Zídek; Antonín Holý
Journal:  Antimicrob Agents Chemother       Date:  2003-12       Impact factor: 5.191

7.  Design and development of oral drugs for the prophylaxis and treatment of smallpox infection.

Authors:  George R Painter; Karl Y Hostetler
Journal:  Trends Biotechnol       Date:  2004-08       Impact factor: 19.536

8.  Praziquantel, a new board-spectrum antischistosomal agent.

Authors:  R Gönnert; P Andrews
Journal:  Z Parasitenkd       Date:  1977-07-21

9.  Esterification of cidofovir with alkoxyalkanols increases oral bioavailability and diminishes drug accumulation in kidney.

Authors:  Stephanie L Ciesla; Julissa Trahan; W Brad Wan; James R Beadle; Kathy A Aldern; George R Painter; Karl Y Hostetler
Journal:  Antiviral Res       Date:  2003-08       Impact factor: 5.970

10.  Effect of oral treatment with hexadecyloxypropyl-[(S)-9-(3-hydroxy-2- phosphonylmethoxypropyl)adenine] [(S)-HPMPA] or octadecyloxyethyl-(S)-HPMPA on cowpox or vaccinia virus infections in mice.

Authors:  Debra C Quenelle; Deborah J Collins; Bridgett P Herrod; Kathy A Keith; Julissa Trahan; James R Beadle; Karl Y Hostetler; Earl R Kern
Journal:  Antimicrob Agents Chemother       Date:  2007-09-10       Impact factor: 5.191
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  5 in total

1.  Ultrastructural analysis of miltefosine-induced surface membrane damage in adult Schistosoma mansoni BH strain worms.

Authors:  Humberto Gonçalves Bertão; Renata Alexandre Ramos da Silva; Rafael José R Padilha; Mônica Camelo Pessôa de Azevedo Albuquerque; Gandhi Rádis-Baptista
Journal:  Parasitol Res       Date:  2012-01-04       Impact factor: 2.289

2.  Effect of phenyl vinyl sulphone cysteine protease inhibitor on Schistosoma mansoni: in vitro and in vivo experimental studies.

Authors:  Manal Salah El-Din Mahmoud; Ayman Nabil Ibrahim; Abeer Fathy Badawy; Nourhan Mohamed Abdelmoniem
Journal:  J Parasit Dis       Date:  2017-06-22

Review 3.  Novel therapeutic and prevention approaches for schistosomiasis: review.

Authors:  Rashika A F El Ridi; Hatem A-M Tallima
Journal:  J Adv Res       Date:  2012-06-23       Impact factor: 10.479

4.  Comparative Molluscicidal and Schistosomicidal Potentiality of Two Solanum Species and Its Isolated Glycoalkaloids.

Authors:  Muhammad A Alsherbiny; Shymaa A El Badawy; Hesham Elbedewy; Shahira M Ezzat; Fatma S Elsakhawy; Mostafa A Abdel-Kawy
Journal:  Pharmacognosy Res       Date:  2018 Jan-Mar

5.  Schistosomicidal activity of the essential oil of Ageratum conyzoides L. (Asteraceae) against adult Schistosoma mansoni worms.

Authors:  Nathalya I de Melo; Lizandra G Magalhaes; Carlos E de Carvalho; Kamila A L Wakabayashi; Gabriela de P Aguiar; Rafael C Ramos; Andre L L Mantovani; Izabel C C Turatti; Vanderlei Rodrigues; Milton Groppo; Wilson R Cunha; Rodrigo C S Veneziani; Antônio E M Crotti
Journal:  Molecules       Date:  2011-01-18       Impact factor: 4.411
  5 in total

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