OBJECTIVES: To investigate the association between job strain and elevated levels of plasminogen activator inhibitor-1. METHODS: A cross-sectional study was carried out, comprising 1,954 actively working men and women between the ages of 19-64 years. Data were collected by questionnaire, clinical examination and blood samples. RESULTS: Elevated plasminogen activator inhibitor-1 levels were more commonly noted in women exposed to job strain than in unexposed women (odds ratio 1.33; 95% confidence interval 1.06-1.65). This association remained after we had adjusted for factors related to behaviour and general health, but became close to 1 after we had adjusted for factors related to the metabolic syndrome. For men, no association between job strain and elevated levels of plasminogen activator inhibitor-1 was observed (odds ratio 0.94; 95% confidence interval 0.71-1.26). CONCLUSIONS: Women exposed to job strain were more inclined to respond with increased plasminogen activator inhibitor-1 than men. In this first study on the association between job strain and plasminogen activator inhibitor-1 in both men and women, we observed such a relationship among women but not among men. The data support the notion that job strain might affect the risk of coronary heart disease by influencing an important cardiovascular system: the metabolic syndrome. Copyright 2004 Springer-Verlag
OBJECTIVES: To investigate the association between job strain and elevated levels of plasminogen activator inhibitor-1. METHODS: A cross-sectional study was carried out, comprising 1,954 actively working men and women between the ages of 19-64 years. Data were collected by questionnaire, clinical examination and blood samples. RESULTS: Elevated plasminogen activator inhibitor-1 levels were more commonly noted in women exposed to job strain than in unexposed women (odds ratio 1.33; 95% confidence interval 1.06-1.65). This association remained after we had adjusted for factors related to behaviour and general health, but became close to 1 after we had adjusted for factors related to the metabolic syndrome. For men, no association between job strain and elevated levels of plasminogen activator inhibitor-1 was observed (odds ratio 0.94; 95% confidence interval 0.71-1.26). CONCLUSIONS:Women exposed to job strain were more inclined to respond with increased plasminogen activator inhibitor-1 than men. In this first study on the association between job strain and plasminogen activator inhibitor-1 in both men and women, we observed such a relationship among women but not among men. The data support the notion that job strain might affect the risk of coronary heart disease by influencing an important cardiovascular system: the metabolic syndrome. Copyright 2004 Springer-Verlag
Authors: T Theorell; A Tsutsumi; J Hallquist; C Reuterwall; C Hogstedt; P Fredlund; N Emlund; J V Johnson Journal: Am J Public Health Date: 1998-03 Impact factor: 9.308
Authors: R Peter; L Alfredsson; N Hammar; J Siegrist; T Theorell; P Westerholm Journal: J Epidemiol Community Health Date: 1998-09 Impact factor: 3.710