Literature DB >> 15102816

Protection elicited by a double leucine and pantothenate auxotroph of Mycobacterium tuberculosis in guinea pigs.

Samantha L Sampson1, Christopher C Dascher, Vasan K Sambandamurthy, Robert G Russell, William R Jacobs, Barry R Bloom, Mary K Hondalus.   

Abstract

We developed a live, fully attenuated Mycobacterium tuberculosis vaccine candidate strain with two independent attenuating auxotrophic mutations in leucine and pantothenate biosynthesis. The deltaleuD deltapanCD double auxotroph is fully attenuated in the SCID mouse model and highly immunogenic and protective in the extremely sensitive guinea pig tuberculosis model, reducing both bacterial burden and disease pathology.

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Year:  2004        PMID： 15102816      PMCID： PMC387862          DOI： 10.1128/IAI.72.5.3031-3037.2004

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  27 in total

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Authors:  C Armbruster; W Junker; N Vetter; G Jaksch
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Review 3.  Disseminated bacille Calmette-Guérin disease after vaccination: case report and review.

Authors:  E A Talbot; M D Perkins; S F Silva; R Frothingham
Journal:  Clin Infect Dis       Date:  1997-06       Impact factor: 9.079

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Authors:  Lise Brandt; Joana Feino Cunha; Anja Weinreich Olsen; Ben Chilima; Penny Hirsch; Rui Appelberg; Peter Andersen
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5.  Effects of infection with atypical mycobacteria on BCG vaccination and tuberculosis.

Authors:  C E Palmer; M W Long
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6.  Mycobacterial antigens exacerbate disease manifestations in Mycobacterium tuberculosis-infected mice.

Authors:  Andre L Moreira; Liana Tsenova; Melles Haile Aman; Linda-Gail Bekker; Sherry Freeman; Bande Mangaliso; Ulf Schröder; Jaishree Jagirdar; William N Rom; Michael G Tovey; Victoria H Freedman; Gilla Kaplan
Journal:  Infect Immun       Date:  2002-04       Impact factor: 3.441

7.  Immunization with a mycobacterial lipid vaccine improves pulmonary pathology in the guinea pig model of tuberculosis.

Authors:  Christopher C Dascher; Kenji Hiromatsu; Xiaowei Xiong; Caroline Morehouse; Gerald Watts; Gui Liu; David N McMurray; Kenneth P LeClair; Steven A Porcelli; Michael B Brenner
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8.  Evidence for occurrence of the ESAT-6 protein in Mycobacterium tuberculosis and virulent Mycobacterium bovis and for its absence in Mycobacterium bovis BCG.

Authors:  M Harboe; T Oettinger; H G Wiker; I Rosenkrands; P Andersen
Journal:  Infect Immun       Date:  1996-01       Impact factor: 3.441

9.  A pantothenate auxotroph of Mycobacterium tuberculosis is highly attenuated and protects mice against tuberculosis.

Authors:  Vasan K Sambandamurthy; Xiaojuan Wang; Bing Chen; Robert G Russell; Steven Derrick; Frank M Collins; Sheldon L Morris; William R Jacobs
Journal:  Nat Med       Date:  2002-09-09       Impact factor: 53.440

Review 10.  Bacillus Calmette-Guérin complications in children born to HIV-1-infected women with a review of the literature.

Authors:  K L O'Brien; A J Ruff; M A Louis; J Desormeaux; D J Joseph; M McBrien; J Coberly; R Boulos; N A Halsey
Journal:  Pediatrics       Date:  1995-03       Impact factor: 7.124
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  67 in total

1.  Evaluation of a temperature-restricted, mucosal tuberculosis vaccine in guinea pigs.

Authors:  Tuhina Gupta; Monica LaGatta; Shelly Helms; Rebecca L Pavlicek; Simon O Owino; Kaori Sakamoto; Tamas Nagy; Stephen B Harvey; Mark Papania; Stephanie Ledden; Kevin T Schultz; Candace McCombs; Frederick D Quinn; Russell K Karls
Journal:  Tuberculosis (Edinb)       Date:  2018-10-19       Impact factor: 3.131

2.  Polyphosphate is an extracellular signal that can facilitate bacterial survival in eukaryotic cells.

Authors:  Ramesh Rijal; Louis A Cadena; Morgan R Smith; Joseph F Carr; Richard H Gomer
Journal:  Proc Natl Acad Sci U S A       Date:  2020-12-02       Impact factor: 11.205

3.  Long-term protection against tuberculosis following vaccination with a severely attenuated double lysine and pantothenate auxotroph of Mycobacterium tuberculosis.

Authors:  Vasan K Sambandamurthy; Steven C Derrick; Kripa V Jalapathy; Bing Chen; Robert G Russell; Sheldon L Morris; William R Jacobs
Journal:  Infect Immun       Date:  2005-02       Impact factor: 3.441

4.  Gamma interferon and monophosphoryl lipid A-trehalose dicorynomycolate are efficient adjuvants for Mycobacterium tuberculosis multivalent acellular vaccine.

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Review 5.  Tuberculosis vaccine types and timings.

Authors:  Ian M Orme
Journal:  Clin Vaccine Immunol       Date:  2014-12-24

Review 6.  Mycobacterium tuberculosis in the Face of Host-Imposed Nutrient Limitation.

Authors:  Michael Berney; Linda Berney-Meyer
Journal:  Microbiol Spectr       Date:  2017-06

7.  A Macrophage Infection Model to Predict Drug Efficacy Against Mycobacterium Tuberculosis.

Authors:  Kaitlyn Schaaf; Virginia Hayley; Alexander Speer; Frank Wolschendorf; Michael Niederweis; Olaf Kutsch; Jim Sun
Journal:  Assay Drug Dev Technol       Date:  2016-06-21       Impact factor: 1.738

8.  Characterization of the protective T-cell response generated in CD4-deficient mice by a live attenuated Mycobacterium tuberculosis vaccine.

Authors:  Steven C Derrick; Teresa H Evering; Vasan K Sambandamurthy; Kripa V Jalapathy; Tsungda Hsu; Bing Chen; Mei Chen; Robert G Russell; Ana Paula Junqueira-Kipnis; Ian M Orme; Steven A Porcelli; William R Jacobs; Sheldon L Morris
Journal:  Immunology       Date:  2006-10-31       Impact factor: 7.397

9.  Robust immunity to an auxotrophic Mycobacterium bovis BCG-VLP prime-boost HIV vaccine candidate in a nonhuman primate model.

Authors:  Gerald K Chege; Wendy A Burgers; Helen Stutz; Ann E Meyers; Rosamund Chapman; Agano Kiravu; Rubina Bunjun; Enid G Shephard; William R Jacobs; Edward P Rybicki; Anna-Lise Williamson
Journal:  J Virol       Date:  2013-02-28       Impact factor: 5.103

10.  Vaccine-mediated immunity to experimental Mycobacterium tuberculosis is not impaired in the absence of Toll-like receptor 9.

Authors:  Archana Gopalakrishnan; Jillian Dietzold; Padmini Salgame
Journal:  Cell Immunol       Date:  2015-12-30       Impact factor: 4.868
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