Literature DB >> 15101755

A strategy for exploiting the pseudosymmetry of the C1-C13 stretch of discodermolide.

Kathlyn A Parker1, Ioannis A Katsoulis.   

Abstract

[reaction: see text] The pseudo-C(2)() symmetry of the C1 to C13 stretch of the discodermolide structure offers a potential strategic advantage for synthetic design. Two approaches based on this recognition were devised, and one was shown to be effective in a model series.

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Year:  2004        PMID: 15101755     DOI: 10.1021/ol049735p

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  3 in total

1.  Asymmetric synthesis of D-ribo-phytosphingosine from 1-tetradecyne and (4-methoxyphenoxy)acetaldehyde.

Authors:  Zheng Liu; Hoe-Sup Byun; Robert Bittman
Journal:  J Org Chem       Date:  2010-07-02       Impact factor: 4.354

2.  (+)-Discodermolide: Total Synthesis, Construction of Novel Analogues, and Biological Evaluation.

Authors:  Amos B Smith; B Scott Freeze
Journal:  Tetrahedron       Date:  2007-01-07       Impact factor: 2.457

3.  Synthesis of (+)-sch 642305 by a biomimetic transannular Michael reaction.

Authors:  Barry B Snider; Jingye Zhou
Journal:  Org Lett       Date:  2006-03-30       Impact factor: 6.005

  3 in total

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