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Literature DB >> 15100412

Genomic analysis of the host response to hepatitis B virus infection.

Stefan Wieland¹, Robert Thimme, Robert H Purcell, Francis V Chisari.

Abstract

Previous studies in hepatitis B virus (HBV)-infected humans and chimpanzees suggest that control of HBV infection involves the cells, effector functions, and molecular mediators of the immune response. The objective of the current study was to identify, in the liver of acutely HBV-infected chimpanzees, the spectrum of virus-induced and immune response-related genes that regulate the infection. The results demonstrate that HBV does not induce any genes during entry and expansion, suggesting it is a stealth virus early in the infection. In contrast, a large number of T cell-derived IFN-gamma-regulated genes are induced in the liver during viral clearance, reflecting the impact of an adaptive T cell response that inhibits viral replication and kills infected cells, thereby terminating the infection.

Entities: Disease Gene Species

Mesh：

Year: 2004 PMID： 15100412 PMCID： PMC404103 DOI： 10.1073/pnas.0401771101

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

43 in total

Review 1. Delivering the kiss of death.

Authors: Christina M Trambas; Gillian M Griffiths
Journal: Nat Immunol Date: 2003-05 Impact factor: 25.606

2. ISG20, a new interferon-induced RNase specific for single-stranded RNA, defines an alternative antiviral pathway against RNA genomic viruses.

Authors: Lucile Espert; Genevieve Degols; Celine Gongora; Danielle Blondel; Bryan R Williams; Robert H Silverman; Nadir Mechti
Journal: J Biol Chem Date: 2003-02-19 Impact factor: 5.157

3. Nuclear import of hepatitis B virus capsids and release of the viral genome.

Authors: Birgit Rabe; Angelika Vlachou; Nelly Panté; Ari Helenius; Michael Kann
Journal: Proc Natl Acad Sci U S A Date: 2003-08-08 Impact factor: 11.205

Review 4. The interferon in TLR signaling: more than just antiviral.

Authors: Paul J Hertzog; Luke A O'Neill; John A Hamilton
Journal: Trends Immunol Date: 2003-10 Impact factor: 16.687

5. Expansion and contraction of the hepatitis B virus transcriptional template in infected chimpanzees.

Authors: Stefan F Wieland; Hans Christian Spangenberg; Robert Thimme; Robert H Purcell; Francis V Chisari
Journal: Proc Natl Acad Sci U S A Date: 2004-02-05 Impact factor: 11.205

Review 6. Hepatitis B virus immunopathogenesis.

Authors: F V Chisari; C Ferrari
Journal: Annu Rev Immunol Date: 1995 Impact factor: 28.527

7. A new gamma-interferon-inducible promoter and splice variants of an anti-angiogenic human tRNA synthetase.

Authors: Jianming Liu; Eveline Shue; Karla L Ewalt; Paul Schimmel
Journal: Nucleic Acids Res Date: 2004-02-02 Impact factor: 16.971

8. HLA-A31- and HLA-Aw68-restricted cytotoxic T cell responses to a single hepatitis B virus nucleocapsid epitope during acute viral hepatitis.

Authors: G Missale; A Redeker; J Person; P Fowler; S Guilhot; H J Schlicht; C Ferrari; F V Chisari
Journal: J Exp Med Date: 1993-03-01 Impact factor: 14.307

9. The cytotoxic T lymphocyte response to multiple hepatitis B virus polymerase epitopes during and after acute viral hepatitis.

Authors: B Rehermann; P Fowler; J Sidney; J Person; A Redeker; M Brown; B Moss; A Sette; F V Chisari
Journal: J Exp Med Date: 1995-03-01 Impact factor: 14.307

9. Triple positivity of HBsAg, anti-HCV antibody, and HIV and their influence on CD4+ lymphocyte levels in the highly HIV infected population of Abeokuta, Nigeria.

Authors: Sandra Olukemi Ogwu-Richard; David Ajiboye Ojo; Olusola Abiodun Akingbade; Iheanyi Omezuruike Okonko
Journal: Afr Health Sci Date: 2015-09 Impact factor: 0.927

Review 10. Viruses associated with human cancer.

Authors: Margaret E McLaughlin-Drubin; Karl Munger
Journal: Biochim Biophys Acta Date: 2007-12-23

Genomic analysis of the host response to hepatitis B virus infection.

Review 1. Delivering the kiss of death.

2. ISG20, a new interferon-induced RNase specific for single-stranded RNA, defines an alternative antiviral pathway against RNA genomic viruses.

3. Nuclear import of hepatitis B virus capsids and release of the viral genome.

Review 4. The interferon in TLR signaling: more than just antiviral.

5. Expansion and contraction of the hepatitis B virus transcriptional template in infected chimpanzees.

Review 6. Hepatitis B virus immunopathogenesis.

7. A new gamma-interferon-inducible promoter and splice variants of an anti-angiogenic human tRNA synthetase.

8. HLA-A31- and HLA-Aw68-restricted cytotoxic T cell responses to a single hepatitis B virus nucleocapsid epitope during acute viral hepatitis.

9. The cytotoxic T lymphocyte response to multiple hepatitis B virus polymerase epitopes during and after acute viral hepatitis.

10. Identification of a novel gene family that includes the interferon-inducible human genes 6-16 and ISG12.

Review 1. Interferon-lambda in the immune response to hepatitis B virus and hepatitis C virus.

Review 2. Animal models and the molecular biology of hepadnavirus infection.

Review 3. Stealth and cunning: hepatitis B and hepatitis C viruses.

4. Blockade of NKG2D on NKT cells prevents hepatitis and the acute immune response to hepatitis B virus.

5. Limited hepatitis B virus replication space in the chronically hepatitis C virus-infected liver.

Review 6. Innate and Adaptive Immune Regulation During Chronic Viral Infections.

Review 7. Immune responses to HCV and other hepatitis viruses.

8. Role of immunoproteasome catalytic subunits in the immune response to hepatitis B virus.

9. Triple positivity of HBsAg, anti-HCV antibody, and HIV and their influence on CD4+ lymphocyte levels in the highly HIV infected population of Abeokuta, Nigeria.

Review 10. Viruses associated with human cancer.