Literature DB >> 15098819

Regulating preimplantation genetic diagnosis--how to control PGD.

Naoki Takeshita1, Harumi Kubo.   

Abstract

PURPOSE: To assess the regulations for Preimplantation Genetic Diagnosis (PGD). How to regulate and control PGD. Is any special licensing procedure necessary?
METHODS: A review of the statements of the organization and the Japan Society of Obstetrics and Gynecology (JSOG). Also, we assess the JSOG guidelines for PGD and the statements on diagnosis of genetic diseases of the Japan Society of Human Genetics. We discuss extra licenses and qualifications for laboratories, staff, and directors.
RESULTS: At present, there are no regulations governing PGD for laboratories, scientists, directors, and staff. Regulations are set by committees and organizations of the countries involved. We don't have any worldwide system of controls. In Japan, we are considering regulations in the fields of reproduction and genetics.
CONCLUSIONS: PGD requires high-level techniques in taking samples, and high-level knowledge about genetic diseases. In diagnosis, we have to be as close to 100% accurate as possible. However, samples for PGD are so small that there is always a risk of failure. Also, we are required to have highly specialized knowledge about reproduction and genetics. In Japan, JSOG has a plan to join with the Society for Investigating Infertility and Society for Genetics.

Entities:  

Keywords:  Genetics and Reproduction; Japan Society of Obstetrics and Gynecology

Mesh:

Year:  2004        PMID: 15098819      PMCID: PMC3468237          DOI: 10.1023/b:jarg.0000017230.12954.90

Source DB:  PubMed          Journal:  J Assist Reprod Genet        ISSN: 1058-0468            Impact factor:   3.412


  5 in total

1.  ESHRE Preimplantation Genetic Diagnosis Consortium: data collection III (May 2001).

Authors: 
Journal:  Hum Reprod       Date:  2002-01       Impact factor: 6.918

2.  Clinical experience of sex determination by fluorescent in-situ hybridization for preimplantation genetic diagnosis.

Authors:  C Staessen; E Van Assche; H Joris; M Bonduelle; M Vandervorst; I Liebaers; A Van Steirteghem
Journal:  Mol Hum Reprod       Date:  1999-04       Impact factor: 4.025

3.  Karyotyping of human oocytes by chromosomal analysis of the second polar bodies.

Authors:  Y Verlinsky; S Evsikov
Journal:  Mol Hum Reprod       Date:  1999-02       Impact factor: 4.025

4.  Pregnancies from biopsied human preimplantation embryos sexed by Y-specific DNA amplification.

Authors:  A H Handyside; E H Kontogianni; K Hardy; R M Winston
Journal:  Nature       Date:  1990-04-19       Impact factor: 49.962

5.  Diagnosis of major chromosome aneuploidies in human preimplantation embryos.

Authors:  S Munné; A Lee; Z Rosenwaks; J Grifo; J Cohen
Journal:  Hum Reprod       Date:  1993-12       Impact factor: 6.918

  5 in total

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