| Literature DB >> 15095417 |
Elzbieta Mikiciuk-Olasik1, Katarzyna Baszczak-Swiatkiewiz, Elzbieta Zurek, Urszula Krajewska, Marek Rózalski, Rafał Kruszyński, Tadeusz J Bartczak.
Abstract
Some derivatives of quinazoline and 1, 2-dihydroquinazoline N(3)-oxide were synthesised and their cytotoxic activities against human leukaemia HL-60 cells under hypoxic and aerobic conditions were tested and compared to tirapazamine as the reference compound. Compound 8 showed 5-fold higher toxicity under hypoxic conditions than in normal oxygen atmosphere. The structure of quinazoline derivatives was established by X-ray crystal structure analysis.Entities:
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Year: 2004 PMID： 15095417 DOI： 10.1002/ardp.200100656
Source DB: PubMed Journal: Arch Pharm (Weinheim) ISSN： 0365-6233 Impact factor: 3.751