OBJECTIVE: To measure the incidence of invasive cervical cancer (ICC) in US women infected with HIV. DESIGN: Multicenter prospective cohort study, conducted between October 1994, and September 2001. SETTING: HIV research centers operating as six urban consortia in the Women's Interagency HIV Study. SUBJECTS: A total of 2131 women (462 HIV seronegative, 1661 HIV seropositive, and eight seroconverters). Women with a history of hysterectomy or of cervical cancer at baseline evaluation were excluded. INTERVENTION: Cervical cytology obtained at 6-month intervals, with a colposcopy referral threshold of atypia, followed by individualized treatment. MAIN OUTCOME MEASURE: ICC diagnoses obtained from study databases and regional cancer registries and confirmed by a gynecologic pathologist. RESULTS: No incident ICC were observed in HIV seronegative women during 2375 woman-years of observation. During 8260 woman-years of observation, eight putative incident cases of cervical cancer were identified in HIV seropositive women, but only one was confirmed, yielding an incidence rate of 1.2/10 000 woman-years (95% confidence interval, 0.3-6.7/10 000 woman-years). The difference in incidence between HIV seropositive and seronegative women was not significant (P = 1.0). CONCLUSION: ICC is uncommon in HIV-infected US women participating in a regular prevention program.
OBJECTIVE: To measure the incidence of invasive cervical cancer (ICC) in US women infected with HIV. DESIGN: Multicenter prospective cohort study, conducted between October 1994, and September 2001. SETTING: HIV research centers operating as six urban consortia in the Women's Interagency HIV Study. SUBJECTS: A total of 2131 women (462 HIV seronegative, 1661 HIV seropositive, and eight seroconverters). Women with a history of hysterectomy or of cervical cancer at baseline evaluation were excluded. INTERVENTION: Cervical cytology obtained at 6-month intervals, with a colposcopy referral threshold of atypia, followed by individualized treatment. MAIN OUTCOME MEASURE: ICC diagnoses obtained from study databases and regional cancer registries and confirmed by a gynecologic pathologist. RESULTS: No incident ICC were observed in HIV seronegative women during 2375 woman-years of observation. During 8260 woman-years of observation, eight putative incident cases of cervical cancer were identified in HIV seropositive women, but only one was confirmed, yielding an incidence rate of 1.2/10 000 woman-years (95% confidence interval, 0.3-6.7/10 000 woman-years). The difference in incidence between HIV seropositive and seronegative women was not significant (P = 1.0). CONCLUSION: ICC is uncommon in HIV-infected US women participating in a regular prevention program.
Authors: L Stewart Massad; Christopher B Pierce; Howard Minkoff; D Heather Watts; Teresa M Darragh; Lorraine Sanchez-Keeland; Rodney L Wright; Christine Colie; Gypsyamber D'Souza Journal: Int J Cancer Date: 2013-10-29 Impact factor: 7.396
Authors: L Stewart Massad; Charlesnika T Evans; Kathleen M Weber; Johanna L Goderre; Nancy A Hessol; Donna Henry; Christine Colie; Howard D Strickler; D Heather Watts; Tracey E Wilson Journal: Obstet Gynecol Date: 2010-10 Impact factor: 7.661
Authors: L Stewart Massad; Kathleen M Weber; Tracey E Wilson; Johanna L Goderre; Nancy A Hessol; Donna Henry; Christine Colie; Howard D Strickler; Alexandra M Levine; D Heather Watts; Charlesnika T Evans Journal: J Low Genit Tract Dis Date: 2012-04 Impact factor: 1.925
Authors: L Stewart Massad; Xianhong Xie; Gypsyamber D'Souza; Teresa M Darragh; Howard Minkoff; Rodney Wright; Christine Colie; Lorraine Sanchez-Keeland; Howard D Strickler Journal: Am J Obstet Gynecol Date: 2014-12-10 Impact factor: 8.661
Authors: Luigino Dal Maso; Silvia Franceschi; Mauro Lise; Priscilla Sassoli De' Bianchi; Jerry Polesel; Florio Ghinelli; Fabio Falcini; Alba C Finarelli Journal: BMC Cancer Date: 2010-06-21 Impact factor: 4.430
Authors: L Stewart Massad; Charlesnika T Evans; Gypsyamber D'Souza; Teresa Darragh; Howard Minkoff; Donna Henry; Lakshmi Goparaju; Laila I Muderspach; D Heather Watts Journal: J Low Genit Tract Dis Date: 2008-07 Impact factor: 1.925
Authors: L Stewart Massad; Eric C Seaberg; D Heather Watts; Howard Minkoff; Alexandra M Levine; Donna Henry; Christine Colie; Teresa M Darragh; Nancy A Hessol Journal: Cancer Date: 2009-02-01 Impact factor: 6.860