Literature DB >> 15085189

Insig: a significant integrator of nutrient and hormonal signals.

Alan D Attie1.   

Abstract

Lipogenesis is regulated by sterols and by insulin through the regulated expression and activation of the sterol regulatory element-binding proteins (SREBPs). A new study shows one way in which sterol and insulin regulation can be decoupled. In transgenic mice overexpressing a protein that regulates SREBP activation, lipogenesis is more sensitive to cholesterol and less sensitive to insulin.

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Year:  2004        PMID： 15085189      PMCID： PMC385410          DOI： 10.1172/JCI21450

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  18 in total

Review 1.  SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver.

Authors:  Jay D Horton; Joseph L Goldstein; Michael S Brown
Journal:  J Clin Invest       Date:  2002-05       Impact factor: 14.808

2.  Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta.

Authors:  J J Repa; G Liang; J Ou; Y Bashmakov; J M Lobaccaro; I Shimomura; B Shan; M S Brown; J L Goldstein; D J Mangelsdorf
Journal:  Genes Dev       Date:  2000-11-15       Impact factor: 11.361

3.  Insulin inhibits transcription of IRS-2 gene in rat liver through an insulin response element (IRE) that resembles IREs of other insulin-repressed genes.

Authors:  J Zhang; J Ou; Y Bashmakov; J D Horton; M S Brown; J L Goldstein
Journal:  Proc Natl Acad Sci U S A       Date:  2001-03-20       Impact factor: 11.205

4.  Increased expression of the sterol regulatory element-binding protein-1 gene in insulin receptor substrate-2(-/-) mouse liver.

Authors:  K Tobe; R Suzuki; M Aoyama; T Yamauchi; J Kamon; N Kubota; Y Terauchi; J Matsui; Y Akanuma; S Kimura; J Tanaka; M Abe; J Ohsumi; R Nagai; T Kadowaki
Journal:  J Biol Chem       Date:  2001-08-23       Impact factor: 5.157

5.  Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice.

Authors:  Naoya Yahagi; Hitoshi Shimano; Alyssa H Hasty; Takashi Matsuzaka; Tomohiro Ide; Tomohiro Yoshikawa; Michiyo Amemiya-Kudo; Sachiko Tomita; Hiroaki Okazaki; Yoshiaki Tamura; Yoko Iizuka; Ken Ohashi; Jun-Ichi Osuga; Kenji Harada; Takanari Gotoda; Ryozo Nagai; Shun Ishibashi; Nobuhiro Yamada
Journal:  J Biol Chem       Date:  2002-03-28       Impact factor: 5.157

6.  Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis.

Authors:  Luke J Engelking; Hiroshi Kuriyama; Robert E Hammer; Jay D Horton; Michael S Brown; Joseph L Goldstein; Guosheng Liang
Journal:  J Clin Invest       Date:  2004-04       Impact factor: 14.808

7.  Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins.

Authors:  Daisuke Yabe; Michael S Brown; Joseph L Goldstein
Journal:  Proc Natl Acad Sci U S A       Date:  2002-09-19       Impact factor: 11.205

8.  Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER.

Authors:  Tong Yang; Peter J Espenshade; Michael E Wright; Daisuke Yabe; Yi Gong; Ruedi Aebersold; Joseph L Goldstein; Michael S Brown
Journal:  Cell       Date:  2002-08-23       Impact factor: 41.582

9.  Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction.

Authors:  Pere Puigserver; James Rhee; Jerry Donovan; Christopher J Walkey; J Cliff Yoon; Francesco Oriente; Yukari Kitamura; Jennifer Altomonte; Hengjiang Dong; Domenico Accili; Bruce M Spiegelman
Journal:  Nature       Date:  2003-05-18       Impact factor: 49.962

10.  Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c.

Authors:  Guosheng Liang; Jian Yang; Jay D Horton; Robert E Hammer; Joseph L Goldstein; Michael S Brown
Journal:  J Biol Chem       Date:  2002-01-08       Impact factor: 5.157
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  6 in total

1.  FoxO1 Is Required for Most of the Metabolic and Hormonal Perturbations Produced by Hepatic Insulin Receptor Deletion in Male Mice.

Authors:  Alisha V Ling; Mary E Gearing; Ivana Semova; Dong-Ju Shin; Rebecca Clements; Zon W Lai; Sudha B Biddinger
Journal:  Endocrinology       Date:  2018-03-01       Impact factor: 4.736

2.  Short-term arginine deprivation results in large-scale modulation of hepatic gene expression in both normal and tumor cells: microarray bioinformatic analysis.

Authors:  Hwei Xian Leong; Carl Simkevich; Anne Lesieur-Brooks; Bonnie W Lau; Celine Fugere; Edmond Sabo; Nancy L Thompson
Journal:  Nutr Metab (Lond)       Date:  2006-09-08       Impact factor: 4.169

3.  Insulin and glucose play a role in foam cell formation and function.

Authors:  Pavel N Shashkin; Nitin Jain; Yury I Miller; Benjamin A Rissing; Yuqing Huo; Susanna R Keller; George E Vandenhoff; Jerry L Nadler; Thomas M McIntyre
Journal:  Cardiovasc Diabetol       Date:  2006-06-20       Impact factor: 9.951

4.  Role of miR29c in goose fatty liver is mediated by its target genes that are involved in energy homeostasis and cell growth.

Authors:  Long Liu; Qian Wang; Qianqian Wang; Xing Zhao; Pan Zhao; Tuoyu Geng; Daoqing Gong
Journal:  BMC Vet Res       Date:  2018-11-06       Impact factor: 2.741

5.  Fatty acids homeostasis during fasting predicts protection from chemotherapy toxicity.

Authors:  Marta Barradas; Adrián Plaza; Gonzalo Colmenarejo; Iolanda Lázaro; Luis Filipe Costa-Machado; Roberto Martín-Hernández; Victor Micó; José Luis López-Aceituno; Jesús Herranz; Cristina Pantoja; Hector Tejero; Alberto Diaz-Ruiz; Fatima Al-Shahrour; Lidia Daimiel; Viviana Loria-Kohen; Ana Ramirez de Molina; Alejo Efeyan; Manuel Serrano; Oscar J Pozo; Aleix Sala-Vila; Pablo J Fernandez-Marcos
Journal:  Nat Commun       Date:  2022-09-27       Impact factor: 17.694

6.  The Diurnal Timing of Starvation Differently Impacts Murine Hepatic Gene Expression and Lipid Metabolism - A Systems Biology Analysis Using Self-Organizing Maps.

Authors:  Christiane Rennert; Sebastian Vlaic; Eugenia Marbach-Breitrück; Carlo Thiel; Susanne Sales; Andrej Shevchenko; Rolf Gebhardt; Madlen Matz-Soja
Journal:  Front Physiol       Date:  2018-09-10       Impact factor: 4.566
  6 in total

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