The application of the ERETIC method to 2D-NMR.

As a means of obtaining precise quantitative data in 2D NMR spectroscopy, the use of an electronic reference signal (ERETIC) has been examined. The results presented demonstrate that the ERETIC method can be used in different situations encountered in 2D-NMR spectroscopy: homonuclear and heteronuclear spectra, phased or magnitude mode, symmetrization. The main restriction to introducing ERETIC in 2D spectra could be the need for several spectrometer channels. However, most modern NMR spectrometers are equipped with at least three channels, that allows the implementation of the ERETIC method as reference for 2D-NMR spectroscopy without needing any hardware modification.