Literature DB >> 15081004

Betulinic acid and its derivatives as anti-angiogenic agents.

Rama Mukherjee1, Manu Jaggi, Praveen Rajendran, Mohammad J A Siddiqui, Sanjay K Srivastava, Anand Vardhan, Anand C Burman.   

Abstract

Betulinic acid (1) significantly caused cytotoxicity to endothelial cell line ECV304 (IC(50) 1.26+/-0.44 microg/mL) in a 5-day MTT assay. Novel and more potent derivatives of betulinic acid (2, 4, 6-8) have been synthesized with IC(50) less than 0.4 microg/mL. The endothelial cell specificity against human tumor cell lines DU145, L132, A549, and PA-1 were determined. Further betulinic acid (1) inhibited TLS formation of ECV304 cells on Matrigel(TM) by 5.5% while its derivatives caused an inhibition of 13.1-49.2%.

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Year:  2004        PMID： 15081004     DOI： 10.1016/j.bmcl.2004.02.044

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  14 in total

1.  Betulinic acid decreases ER-negative breast cancer cell growth in vitro and in vivo: role of Sp transcription factors and microRNA-27a:ZBTB10.

Authors:  Susanne U Mertens-Talcott; Giuliana D Noratto; Xiangrong Li; Gabriela Angel-Morales; Michele C Bertoldi; Stephen Safe
Journal:  Mol Carcinog       Date:  2012-03-07       Impact factor: 4.784

2.  The natural product betulinic acid rapidly promotes amyloid-β fibril formation at the expense of soluble oligomers.

Authors:  Matthew S Planchard; Michael A Samel; Amit Kumar; Vijayaraghavan Rangachari
Journal:  ACS Chem Neurosci       Date:  2012-11-21       Impact factor: 4.418

3.  Sequential treatment with betulinic acid followed by 5-fluorouracil shows synergistic cytotoxic activity in ovarian cancer cells.

Authors:  Ying-Jian Wang; Jun-Bao Liu; Yu-Chang Dou
Journal:  Int J Clin Exp Pathol       Date:  2015-01-01

4.  Betulinic acid induces Bax/Bak-independent cytochrome c release in human nasopharyngeal carcinoma cells.

Authors:  Yang Liu; Wenlong Luo
Journal:  Mol Cells       Date:  2012-04-17       Impact factor: 5.034

5.  Betulinic acid induces apoptosis and inhibits hedgehog signalling in rhabdomyosarcoma.

Authors:  M Eichenmüller; B Hemmerlein; D von Schweinitz; R Kappler
Journal:  Br J Cancer       Date:  2010-06-01       Impact factor: 7.640

6.  Pharmacological evaluation of C-3 modified Betulinic acid derivatives with potent anticancer activity.

Authors:  Praveen Rajendran; Manu Jaggi; Manoj K Singh; Rama Mukherjee; Anand C Burman
Journal:  Invest New Drugs       Date:  2007-09-13       Impact factor: 3.850

7.  Betulinic Acid inhibits growth of cultured vascular smooth muscle cells in vitro by inducing g(1) arrest and apoptosis.

Authors:  Raja Kumar Vadivelu; Swee Keong Yeap; Abdul Manaf Ali; Muhajir Hamid; Noorjahan Banu Alitheen
Journal:  Evid Based Complement Alternat Med       Date:  2012-09-27       Impact factor: 2.629

8.  Betulinic acid enhances TGF-β signaling by altering TGF-β receptors partitioning between lipid-raft/caveolae and non-caveolae membrane microdomains in mink lung epithelial cells.

Authors:  C L Chen; C Y Chen; Y P Chen; Y B Huang; M W Lin; D C Wu; H T Huang; M Y Liu; H W Chang; Y C Kao; P H Yang
Journal:  J Biomed Sci       Date:  2016-02-27       Impact factor: 8.410

9.  The efficacy of betulinic acid in triple-negative breast cancer.

Authors:  Daniel Weber; Mixia Zhang; Pengwei Zhuang; Yanjun Zhang; Janelle Wheat; Geoffrey Currie; Zaynab Al-Eisawi
Journal:  SAGE Open Med       Date:  2014-09-29

10.  Syzygium campanulatum korth methanolic extract inhibits angiogenesis and tumor growth in nude mice.

Authors:  Abdalrahim F A Aisha; Zhari Ismail; Khalid M Abu-Salah; Jamshed M Siddiqui; Gheniya Ghafar; Amin Malik Shah Abdul Majid
Journal:  BMC Complement Altern Med       Date:  2013-07-11       Impact factor: 3.659
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