Literature DB >> 15080909

Synthesis and immunomodulatory properties of selected oxazolone derivatives.

Muhammad A Mesaik1, Shagufta Rahat, Khalid M Khan, Muhammad I Choudhary, Shahnaz Murad, Zakiah Ismail, Aqeel Ahmad.   

Abstract

Eleven oxazolone derivatives were synthesized and characterized by (1)H NMR, EI, IR and UV spectroscopic and CHN analysis. Three compounds, 4-[(E)-(4-nitrophenyl)methylidene]-2-phenyl-1,3-oxazol-5(4H)-one (11), 4-[(E)-(4-methoxyphenyl)methylidene]-2-methyl-1,3-oxazol-5-one (12) and 4-[(E)-(4-nitrophenyl)methylidene]-2-methyl-1,3-oxazol-5(4H)-one (13) were screened for phagocyte chemiluminescence, neutrophil chemotaxis, T-cell proliferation, cytokine production from mononuclear cells and cytotoxicity. 4-[(E)-(4-Nitrophenyl)methylidene]-2-methyl-1,3-oxazol-5(4H)-one (13) was found to be the most potent immunomodulator in the series.

Entities:  

Mesh：

Substances：

Year:  2004        PMID： 15080909     DOI： 10.1016/j.bmc.2004.02.034

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  12 in total

1.  Evidence for substrate preorganization in the peptidylglycine α-amidating monooxygenase reaction describing the contribution of ground state structure to hydrogen tunneling.

Authors:  Neil R McIntyre; Edward W Lowe; Jonathan L Belof; Milena Ivkovic; Jacob Shafer; Brian Space; David J Merkler
Journal:  J Am Chem Soc       Date:  2010-11-02       Impact factor: 15.419

2.  A facile and improved synthesis of sildenafil (Viagra) analogs through solid support microwave irradiation possessing tyrosinase inhibitory potential, their conformational analysis and molecular dynamics simulation studies.

Authors:  Khalid M Khan; Ghulam M Maharvi; Mahmud T H Khan; Shahnaz Perveen; Muhammad I Choudhary
Journal:  Mol Divers       Date:  2005       Impact factor: 2.943

3.  Tuning photoinduced intramolecular electron transfer by electron accepting and donating substituents in oxazolones.

Authors:  Gülsiye Oztürk; Hasan Karabıyık; Muhittin Aygün; Serap Alp; Serdar Ozçelik
Journal:  J Fluoresc       Date:  2013-03-15       Impact factor: 2.217

4.  Antioxidant, antiglycation and cytotoxicity evaluation of selected medicinal plants of the Mascarene Islands.

Authors:  Fawzi M Mahomoodally; Anwar H Subratty; Ameenah Gurib-Fakim; Muhammad Iqbal Choudhary
Journal:  BMC Complement Altern Med       Date:  2012-09-29       Impact factor: 3.659

5.  4-(2-Methoxy-benzyl-idene)-2-phenyl-1,3-oxazol-5(4H)-one.

Authors:  Abdullah Mohamed Asiri; Mehmet Akkurt; Islam Ullah Khan; Muhammad N Arshad
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-03-25

6.  Turning the 'mustard oil bomb' into a 'cyanide bomb': aromatic glucosinolate metabolism in a specialist insect herbivore.

Authors:  Einar J Stauber; Petrissa Kuczka; Maike van Ohlen; Birgit Vogt; Tim Janowitz; Markus Piotrowski; Till Beuerle; Ute Wittstock
Journal:  PLoS One       Date:  2012-04-20       Impact factor: 3.240

7.  Synthesis and evaluation of new β-carboline-3-(4-benzylidene)-4H-oxazol-5-one derivatives as antitumor agents.

Authors:  Franciele Cristina Savariz; Mary Ann Foglio; João Ernesto de Carvalho; Ana Lúcia T G Ruiz; Marta C T Duarte; Mauricio Ferreira da Rosa; Emerson Meyer; Maria Helena Sarragiotto
Journal:  Molecules       Date:  2012-05-21       Impact factor: 4.411

8.  New 2-(4-(4-bromophenylsulfonyl)phenyl)-4-arylidene-oxazol-5(4H)-ones: analgesic activity and histopathological assessment.

Authors:  Florica Bărbuceanu; Elena Valentina Roşca; Theodora Venera Apostol; Oana Cristina Şeremet; Constantin Drăghici; Dragoş Paul Mihai; Simona Negreş; George Mihai Niţulescu; Ştefania Felicia Bărbuceanu
Journal:  Rom J Morphol Embryol       Date:  2020 Apr-Jun       Impact factor: 1.033

9.  Synthesis, Antimicrobial, Anti-Virulence and Anticancer Evaluation of New 5(4H)-Oxazolone-Based Sulfonamides.

Authors:  Ahmad J Almalki; Tarek S Ibrahim; Ehab S Taher; Mamdouh F A Mohamed; Mahmoud Youns; Wael A H Hegazy; Amany M M Al-Mahmoudy
Journal:  Molecules       Date:  2022-01-20       Impact factor: 4.411

10.  Dodecatungstophosphoric acid (H3PW 12O40), samarium and ruthenium (III) chloride catalyzed synthesis of unsaturated 2-phenyl-5(4H)-oxazolone derivatives under solvent-free conditions.

Authors:  Ahmad Momeni Tikdari; Samieh Fozooni; Hooshang Hamidian
Journal:  Molecules       Date:  2008-12-18       Impact factor: 4.411
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.