OBJECTIVE: To test the hypothesis that subthalamic nucleus (STN) stimulation in Parkinson disease (PD) patients affects working memory and response inhibition performance, particularly under conditions of high demand on cognitive control. METHODS: To test this hypothesis, spatial working memory (spatial delayed response [SDR]) and response inhibition (Go-No-Go [GNG]) tasks requiring varying levels of cognitive control were administered to patients with PD with previously implanted bilateral STN stimulators (n = 24). Patients did not take PD medications overnight. Data were collected while bilateral stimulators were on and off, counterbalancing the order across subjects. RESULTS: On the SDR task, STN stimulation decreased patients' working memory performance under a high but not low memory load condition (effect of stimulator condition on high load only and condition x load interaction, p < 0.05). On the GNG task, STN stimulation reduced discriminability on a high but not medium inhibition condition (effect of stimulator condition on high inhibition level only, p = 0.05; condition x inhibition level interaction, p = 0.07). CONCLUSION: STN stimulation reduces working memory and response inhibition performance under conditions of greater challenge to cognitive control despite significant improvement of motor function.
OBJECTIVE: To test the hypothesis that subthalamic nucleus (STN) stimulation in Parkinson disease (PD) patients affects working memory and response inhibition performance, particularly under conditions of high demand on cognitive control. METHODS: To test this hypothesis, spatial working memory (spatial delayed response [SDR]) and response inhibition (Go-No-Go [GNG]) tasks requiring varying levels of cognitive control were administered to patients with PD with previously implanted bilateral STN stimulators (n = 24). Patients did not take PD medications overnight. Data were collected while bilateral stimulators were on and off, counterbalancing the order across subjects. RESULTS: On the SDR task, STN stimulation decreased patients' working memory performance under a high but not low memory load condition (effect of stimulator condition on high load only and condition x load interaction, p < 0.05). On the GNG task, STN stimulation reduced discriminability on a high but not medium inhibition condition (effect of stimulator condition on high inhibition level only, p = 0.05; condition x inhibition level interaction, p = 0.07). CONCLUSION: STN stimulation reduces working memory and response inhibition performance under conditions of greater challenge to cognitive control despite significant improvement of motor function.
Authors: Tamara Hershey; Meghan C Campbell; Tom O Videen; Heather M Lugar; Patrick M Weaver; Johanna Hartlein; Morvarid Karimi; Samer D Tabbal; Joel S Perlmutter Journal: Brain Date: 2010-09-20 Impact factor: 13.501
Authors: M C Campbell; M Karimi; P M Weaver; J Wu; D C Perantie; N A Golchin; S D Tabbal; J S Perlmutter; T Hershey Journal: Neuropsychologia Date: 2008-07-19 Impact factor: 3.139
Authors: Laura B Zahodne; Michael S Okun; Kelly D Foote; Hubert H Fernandez; Ramon L Rodriguez; Lindsey Kirsch-Darrow; Dawn Bowers Journal: Clin Neuropsychol Date: 2008-09-23 Impact factor: 3.535