| Literature DB >> 1507649 |
D H Kim1, S H Hyun, S B Shim, K Kobashi.
Abstract
Sodium picosulfate, a laxative, was biotransformed to 4,4'-dihydroxydiphenyl-(2 pyridyl)-methane by intestinal flora that produced a novel sulfotransferase (not sulfatase). The biotransformation was activated by adding phenolic compounds such as phenol, acetaminophen and flavonoids. The enzyme activity related to this biotransformation was the highest in the contents of the caecum region of the intestine. The enzyme activity was 3.0 mumole/hr/g wet feces in humans and 0.75 in rats (pH 8.0). The optimal pH was 9.0.Entities:
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Year: 1992 PMID： 1507649 DOI： 10.1254/jjp.59.1
Source DB: PubMed Journal: Jpn J Pharmacol ISSN： 0021-5198