BACKGROUND:Continuous positive airway pressure (CPAP) remains the treatment of choice for obstructive sleepapnea hypopnea (OSAH). Auto-titrating CPAP (APAP) devices automatically adjust pressure and may improve treatment compliance compared to fixed CPAP (F-CPAP). METHODS: Randomized, prospective, single-blind, crossover trial to compare efficacy, side effects, compliance, patient satisfaction and preference between APAP and F-CPAP therapy in patients with moderate to severe OSAH. There were two treatment periods of 4 weeks each (APAP and F-CPAP), separated by a 2-week washout period. RESULTS:Ten CPAP-naive OSAH patients (9 males) completed the study. They had Mean +/- SD age of 44.9 +/- 9.7 years; body mass index of 35.9 +/- 12.9 kg/m2 and apnea/hypopnea index (AHI) of 47.2 +/- 35.6. Both forms of therapy were equally effective in improving the symptoms and in reducing the AHI. Both forms of therapy were associated with frequent side effects and had similar patient compliance. At the end of the study, more patients (6-1) preferred F-CPAP to A-CPAP therapy. CONCLUSION: A-PAP was as effective as F-CPAP in the treatment of OSAH but was not associated with fewer side effects, better compliance, better satisfaction or increased patient preference.
RCT Entities:
BACKGROUND: Continuous positive airway pressure (CPAP) remains the treatment of choice for obstructive sleep apnea hypopnea (OSAH). Auto-titrating CPAP (APAP) devices automatically adjust pressure and may improve treatment compliance compared to fixed CPAP (F-CPAP). METHODS: Randomized, prospective, single-blind, crossover trial to compare efficacy, side effects, compliance, patient satisfaction and preference between APAP and F-CPAP therapy in patients with moderate to severe OSAH. There were two treatment periods of 4 weeks each (APAP and F-CPAP), separated by a 2-week washout period. RESULTS: Ten CPAP-naive OSAH patients (9 males) completed the study. They had Mean +/- SD age of 44.9 +/- 9.7 years; body mass index of 35.9 +/- 12.9 kg/m2 and apnea/hypopnea index (AHI) of 47.2 +/- 35.6. Both forms of therapy were equally effective in improving the symptoms and in reducing the AHI. Both forms of therapy were associated with frequent side effects and had similar patient compliance. At the end of the study, more patients (6-1) preferred F-CPAP to A-CPAP therapy. CONCLUSION: A-PAP was as effective as F-CPAP in the treatment of OSAH but was not associated with fewer side effects, better compliance, better satisfaction or increased patient preference.
Authors: Marjorie Vennelle; Sandra White; Renata L Riha; Tom W Mackay; Heather M Engleman; Neil J Douglas Journal: Sleep Date: 2010-02 Impact factor: 5.849
Authors: Susheel P Patil; Indu A Ayappa; Sean M Caples; R Joh Kimoff; Sanjay R Patel; Christopher G Harrod Journal: J Clin Sleep Med Date: 2019-02-15 Impact factor: 4.062
Authors: John Fleetham; Najib Ayas; Douglas Bradley; Michael Fitzpatrick; Thomas K Oliver; Debra Morrison; Frank Ryan; Frederick Series; Robert Skomro; Willis Tsai Journal: Can Respir J Date: 2011 Jan-Feb Impact factor: 2.409
Authors: Clete A Kushida; Richard B Berry; Alexander Blau; Tami Crabtree; Ingo Fietze; Meir H Kryger; Samuel T Kuna; G Vernon Pegram; Thomas Penzel Journal: Sleep Date: 2011-08-01 Impact factor: 5.849
Authors: Wietske Richard; Jantine Venker; Cindy den Herder; Dennis Kox; Bob van den Berg; Martin Laman; Harm van Tinteren; Nico de Vries Journal: Eur Arch Otorhinolaryngol Date: 2007-04-19 Impact factor: 2.503
Authors: Stanley Ip; Carolyn D'Ambrosio; Kamal Patel; Ndidiamaka Obadan; Georgios D Kitsios; Mei Chung; Ethan M Balk Journal: Syst Rev Date: 2012-03-08