Literature DB >> 15068088

A solid-phase approach towards the development of 3-aza-6,8-dioxabicyclo[3.2.1]octane scaffolds.

Andrea Trabocchi1, Francesco Mancini, Gloria Menchi, Antonio Guarna.   

Abstract

The development of new strategies for solid-phase synthesis of 3-aza-6,8-dioxabicyclo[3.2.1]octane scaffolds, named BTKa, is described. The preparation was made possible by the combination of three components: amines, alpha-halo-acetophenones, and sugar or tartaric acid derivatives. By anchoring each of the three components it was possible to synthesize BTKa compounds either as amino alcohols or amido esters. The compatibility of the protocols with different classes of amines and substituted alpha-halo-acetophenones was demonstrated.

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 15068088     DOI： 10.1023/b:modi.0000006781.31594.c2

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  10 in total

1.  Synthesis and Applications of Small Molecule Libraries.

Authors:  Lorin A. Thompson; Jonathan A. Ellman
Journal:  Chem Rev       Date:  1996-02-01       Impact factor: 60.622

2.  The Current Status of Heterocyclic Combinatorial Libraries.

Authors:  Adel Nefzi; John M. Ostresh; Richard A. Houghten
Journal:  Chem Rev       Date:  1997-04-01       Impact factor: 60.622

3.  The "One-Bead-One-Compound" Combinatorial Library Method.

Authors:  Kit S. Lam; Michal Lebl; Viktor Krchnák
Journal:  Chem Rev       Date:  1997-04-01       Impact factor: 60.622

Review 4.  Thinking combinatorially.

Authors:  S Kauffman; A D Ellington
Journal:  Curr Opin Chem Biol       Date:  1999-06       Impact factor: 8.822

5.  A Reductive Alkylation Procedure Applicable to Both Solution- and Solid-Phase Syntheses of Secondary Amines.

Authors:  Anna K. Szardenings; Timothy S. Burkoth; Gary C. Look; David A. Campbell
Journal:  J Org Chem       Date:  1996-09-20       Impact factor: 4.354

6.  Reductive Amination of Aldehydes and Ketones with Sodium Triacetoxyborohydride. Studies on Direct and Indirect Reductive Amination Procedures(1).

Authors:  Ahmed F. Abdel-Magid; Kenneth G. Carson; Bruce D. Harris; Cynthia A. Maryanoff; Rekha D. Shah
Journal:  J Org Chem       Date:  1996-05-31       Impact factor: 4.354

Review 7.  Applications of combinatorial technologies to drug discovery. 2. Combinatorial organic synthesis, library screening strategies, and future directions.

Authors:  E M Gordon; R W Barrett; W J Dower; S P Fodor; M A Gallop
Journal:  J Med Chem       Date:  1994-05-13       Impact factor: 7.446

Review 8.  Applications of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial libraries.

Authors:  M A Gallop; R W Barrett; W J Dower; S P Fodor; E M Gordon
Journal:  J Med Chem       Date:  1994-04-29       Impact factor: 7.446

9.  Stereoselective Solid-Phase Synthesis of β-Lactams-A Novel Cyclization/Cleavage Step towards 1-Oxacephams.

Authors:  B Furman; R Thürmer; Z Kałuża; R Lysek; W Voelter; M Chmielewski
Journal:  Angew Chem Int Ed Engl       Date:  1999       Impact factor: 15.336

10.  Use of trichloroacetimidate linker in solid-phase Peptide synthesis.

Authors:  Liang Zeng Yan; John P Mayer
Journal:  J Org Chem       Date:  2003-02-07       Impact factor: 4.354
  10 in total
  1 in total

1.  Relations between Effects and Structure of Small Bicyclic Molecules on the Complex Model System Saccharomyces cerevisiae.

Authors:  Matteo Brilli; Andrea Trabocchi; Tobias Weil; Duccio Cavalieri; Irene Stefanini
Journal:  Front Pharmacol       Date:  2017-03-30       Impact factor: 5.810
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.