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Literature DB >> 15067112

Asymmetric autocatalysis and its implications for the origin of homochirality.

Abstract

An autocatalytic reaction in which the reaction product serves as a catalyst to produce more of itself and to suppress production of its enantiomer serves as a mechanistic model for the evolution of homochirality. The Soai reaction provided experimental confirmation of this concept, nearly 50 years after it was first proposed. This Perspective offers a rationalization of the Soai autocatalytic reaction; accounting for enantiomeric excess and rate observations, that is both simple as well as gratifying in its implications for the chemical origin of life.

Year: 2004 PMID： 15067112 PMCID： PMC395976 DOI： 10.1073/pnas.0308363101

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

15 in total

1. A chiroselective peptide replicator.

Authors: A Saghatelian; Y Yokobayashi; K Soltani; M R Ghadiri
Journal: Nature Date: 2001-02-15 Impact factor: 49.962

2. New Developments in the Origins of the Homochirality of Biologically Relevant Molecules The authors would like to thank the Fonds der Chemischen Industrie.

Authors:
Journal: Angew Chem Int Ed Engl Date: 2000-11-17 Impact factor: 15.336

3. Formation of highly enantioenriched microenvironments by stochastic sorting of conglomerate crystals: a plausible mechanism for generation of enantioenrichment on the prebiotic earth.

Authors: C J Welch
Journal: Chirality Date: 2001-08 Impact factor: 2.437

Asymmetric autocatalysis and its implications for the origin of homochirality.

1. A chiroselective peptide replicator.

2. New Developments in the Origins of the Homochirality of Biologically Relevant Molecules The authors would like to thank the Fonds der Chemischen Industrie.

3. Formation of highly enantioenriched microenvironments by stochastic sorting of conglomerate crystals: a plausible mechanism for generation of enantioenrichment on the prebiotic earth.

4. Chemistry: shattered mirrors.

5. On spontaneous asymmetric synthesis.

6. Kinetic evidence for a tetrameric transition state in the asymmetric autocatalytic alkylation of pyrimidyl aldehydes.

7. Nonlinear effects in asymmetric synthesis. Examples in asymmetric oxidations and aldolization reactions.

8. Chiral symmetry breaking in sodium chlorate crystallizaton.

9. Autocatalytic synthesis of a tetranucleotide analogue.

10. Reflections on spontaneous asymmetric synthesis by amplifying autocatalysis.

1. Recycling Frank: Spontaneous emergence of homochirality in noncatalytic systems.

2. The origin of biological homochirality.

Review 3. The origin of biological homochirality.

4. Self-replication: spelling it out in a chemical background.

5. Toward homochiral protocells in noncatalytic peptide systems.

Review 6. Molecular handedness of life: significance of RNA aminoacylation.

7. Punctuated chirality.

8. Amplification of chirality at solid surfaces.

9. Asymmetric autocatalysis induced by meteoritic amino acids with hydrogen isotope chirality.

10. Discrimination of cryptochirality in chiral isotactic polystyrene by asymmetric autocatalysis.