Literature DB >> 1506328

The IC50: an exactly defined measure of antibiotic sensitivity.

J S Soothill1, R Ward, A J Girling.   

Abstract

The concentration of gentamicin that inhibits the growth of half of an inoculum of Pseudomonas aeruginosa (IC50) was estimated by doing viable bacterial counts with varying concentrations of gentamicin and fitting a probit inhibition curve to the results. This is a more precisely defined measure than the MIC and its standard error is readily calculable.

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Year:  1992        PMID： 1506328     DOI： 10.1093/jac/29.2.137

Source DB:  PubMed          Journal:  J Antimicrob Chemother        ISSN： 0305-7453            Impact factor:   5.790


  16 in total

1.  Mixture-based heterocyclic combinatorial positional scanning libraries: discovery of bicyclic guanidines having potent antifungal activities against Candida albicans and Cryptococcus neoformans.

Authors:  S E Blondelle; E Crooks; J M Ostresh; R A Houghten
Journal:  Antimicrob Agents Chemother       Date:  1999-01       Impact factor: 5.191

Review 2.  Synthetic combinatorial libraries: novel discovery strategy for identification of antimicrobial agents.

Authors:  S E Blondelle; E Pérez-Payá; R A Houghten
Journal:  Antimicrob Agents Chemother       Date:  1996-05       Impact factor: 5.191

3.  The Poisoned Well: Enhancing the Predictive Value of Antimicrobial Susceptibility Testing in the Era of Multidrug Resistance.

Authors:  Thea Brennan-Krohn; Kenneth P Smith; James E Kirby
Journal:  J Clin Microbiol       Date:  2017-05-03       Impact factor: 5.948

4.  Inhibitory effect of a triterpenoid compound, with or without alpha interferon, on hepatitis C virus infection.

Authors:  Takako Watanabe; Naoya Sakamoto; Mina Nakagawa; Sei Kakinuma; Yasuhiro Itsui; Yuki Nishimura-Sakurai; Mayumi Ueyama; Yusuke Funaoka; Akiko Kitazume; Sayuri Nitta; Kei Kiyohashi; Miyako Murakawa; Seishin Azuma; Kiichiro Tsuchiya; Shinya Oooka; Mamoru Watanabe
Journal:  Antimicrob Agents Chemother       Date:  2011-03-28       Impact factor: 5.191

5.  Identification of novel N-(morpholine-4-carbonyloxy) amidine compounds as potent inhibitors against hepatitis C virus replication.

Authors:  Akiko Kusano-Kitazume; Naoya Sakamoto; Yukiko Okuno; Yuko Sekine-Osajima; Mina Nakagawa; Sei Kakinuma; Kei Kiyohashi; Sayuri Nitta; Miyako Murakawa; Seishin Azuma; Yuki Nishimura-Sakurai; Masatoshi Hagiwara; Mamoru Watanabe
Journal:  Antimicrob Agents Chemother       Date:  2011-12-27       Impact factor: 5.191

6.  Rapid identification of compounds with enhanced antimicrobial activity by using conformationally defined combinatorial libraries.

Authors:  S E Blondelle; E Takahashi; R A Houghten; E Pérez-Payá
Journal:  Biochem J       Date:  1996-01-01       Impact factor: 3.857

7.  Local adaptation is associated with zinc tolerance in Pseudomonas endophytes of the metal-hyperaccumulator plant Noccaea caerulescens.

Authors:  H N Fones; H McCurrach; A Mithani; J A C Smith; G M Preston
Journal:  Proc Biol Sci       Date:  2016-05-11       Impact factor: 5.349

8.  Expansion of patient-derived circulating tumor cells from liquid biopsies using a CTC microfluidic culture device.

Authors:  Bee Luan Khoo; Gianluca Grenci; Ying Bena Lim; Soo Chin Lee; Jongyoon Han; Chwee Teck Lim
Journal:  Nat Protoc       Date:  2017-12-07       Impact factor: 13.491

9.  Interaction of Selected Phenylpropenes with Dipalmitoylphosphatidylcholine Membrane and Their Relevance to Antibacterial Activity.

Authors:  Riham Gharib; Amal Najjar; Lizette Auezova; Catherine Charcosset; Hélène Greige-Gerges
Journal:  J Membr Biol       Date:  2017-04-22       Impact factor: 1.843

10.  Agmatine accumulation by Pseudomonas aeruginosa clinical isolates confers antibiotic tolerance and dampens host inflammation.

Authors:  Jennifer L McCurtain; Adam J Gilbertsen; Clayton Evert; Bryan J Williams; Ryan C Hunter
Journal:  J Med Microbiol       Date:  2019-01-22       Impact factor: 2.472
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