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Literature DB >> 1506264

Successful graft of HTLV-I-transformed human T-cells (MT-2) in severe combined immunodeficiency mice treated with anti-asialo GM-1 antibody.

S Ishihara¹, N Tachibana, A Okayama, K Murai, K Tsuda, N Mueller.

Abstract

To develop an experimental model of adult T-cell leukemia/lymphoma in small animals, severe combined immunodeficiency (SCID) mice treated with anti-asialo GM-1 antibody were inoculated with MT-2 cells, a cell line transformed by the human T-cell leukemia virus (HTLV-I). Three mice injected with 4 x 10(7) cells subcutaneously or intramuscularly developed tumors at or near inoculation sites. Immunofluorescent antibody (IFA) staining for HTLV-I structural protein, p19, revealed the specific antigen in the cytoplasm of most cells from tumors and the DNA signals of HTLV-I proviral DNA were also positive in cellular DNA by polymerase chain reaction assay with HTLV-I tax gene primers, SK43/SK44. The MT-2 cells did not invade in mouse organs.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：

Year: 1992 PMID： 1506264 PMCID： PMC5918837 DOI： 10.1111/j.1349-7006.1992.tb00108.x

Source DB: PubMed Journal: Jpn J Cancer Res ISSN： 0910-5050

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1. Occurrence of mature B (IgM+, B220+) and T (CD3+) lymphocytes in scid mice.

Authors: A M Carroll; R R Hardy; M J Bosma
Journal: J Immunol Date: 1989-08-15 Impact factor: 5.422

2. Engraftment of immune-deficient mice with human hematopoietic stem cells.

Authors: S Kamel-Reid; J E Dick
Journal: Science Date: 1988-12-23 Impact factor: 47.728

3. The mouse mutation severe combined immune deficiency (scid) is on chromosome 16.

Authors: G C Bosma; M T Davisson; N R Ruetsch; H O Sweet; L D Shultz; M J Bosma
Journal: Immunogenetics Date: 1989 Impact factor: 2.846

4. Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukaemic T cells.

Authors: I Miyoshi; I Kubonishi; S Yoshimoto; T Akagi; Y Ohtsuki; Y Shiraishi; K Nagata; Y Hinuma
Journal: Nature Date: 1981-12-24 Impact factor: 49.962

5. Growth of human tumors in immune-deficient scid mice and nude mice.

Authors: R A Phillips; M A Jewett; B L Gallie
Journal: Curr Top Microbiol Immunol Date: 1989 Impact factor: 4.291

6. In vivo effects of anti-asialo GM1. I. Reduction of NK activity and enhancement of transplanted tumor growth in nude mice.

Authors: S Habu; H Fukui; K Shimamura; M Kasai; Y Nagai; K Okumura; N Tamaoki
Journal: J Immunol Date: 1981-07 Impact factor: 5.422

7. Human lung tumor growth established in the lung and subcutaneous tissue of mice with severe combined immunodeficiency.

Authors: S Reddy; D Piccione; H Takita; R B Bankert
Journal: Cancer Res Date: 1987-05-01 Impact factor: 12.701

8. Polymerase chain reaction analysis of defective human T-cell leukemia virus type I proviral genomes in leukemic cells of patients with adult T-cell leukemia.

Authors: B Korber; A Okayama; R Donnelly; N Tachibana; M Essex
Journal: J Virol Date: 1991-10 Impact factor: 5.103

9. Infection of the SCID-hu mouse by HIV-1.

Authors: R Namikawa; H Kaneshima; M Lieberman; I L Weissman; J M McCune
Journal: Science Date: 1988-12-23 Impact factor: 47.728

10. Postexposure prophylaxis with zidovudine suppresses human immunodeficiency virus type 1 infection in SCID-hu mice in a time-dependent manner.

Authors: C C Shih; H Kaneshima; L Rabin; R Namikawa; P Sager; J McGowan; J M McCune
Journal: J Infect Dis Date: 1991-03 Impact factor: 5.226

13 in total

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Review 2. Animal models for human T-lymphotropic virus type 1 (HTLV-1) infection and transformation.

Authors: Michael D Lairmore; Lee Silverman; Lee Ratner
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3. Engraftment of precursor lesions of human cutaneous neoplasms onto C.B-17 SCID mice: a useful in vivo experimental model of carcinogenesis in human skin.

Authors: Y Takizawa; T Saida; Y Tokuda; S Dohi; S Ikegawa; Y Ueyama
Journal: Arch Dermatol Res Date: 1995 Impact factor: 3.017

4. Induction of adult T-cell leukemia-like lymphoproliferative disease and its inhibition by adoptive immunotherapy in T-cell-deficient nude rats inoculated with syngeneic human T-cell leukemia virus type 1-immortalized cells.

Authors: T Ohashi; S Hanabuchi; H Kato; Y Koya; F Takemura; K Hirokawa; T Yoshiki; Y Tanaka; M Fujii; M Kannagi
Journal: J Virol Date: 1999-07 Impact factor: 5.103

5. Route of primary HTLV-1 infection regulates HTLV-1 distribution in reservoir organs of infected mice.

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Journal: Exp Ther Med Date: 2010-12-02 Impact factor: 2.447

6. Human immunodeficiency virus type 1 pathobiology studied in humanized BALB/c-Rag2-/-gammac-/- mice.

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Journal: J Virol Date: 2006-12-20 Impact factor: 5.103

7. Rapid tumor formation of human T-cell leukemia virus type 1-infected cell lines in novel NOD-SCID/gammac(null) mice: suppression by an inhibitor against NF-kappaB.

Authors: M Zahidunnabi Dewan; Kazuo Terashima; Midori Taruishi; Hideki Hasegawa; Mamoru Ito; Yuetsu Tanaka; Naoki Mori; Tetsutaro Sata; Yoshio Koyanagi; Michiyuki Maeda; Yoko Kubuki; Akihiko Okayama; Masahiro Fujii; Naoki Yamamoto
Journal: J Virol Date: 2003-05 Impact factor: 5.103