Literature DB >> 1506036

Antidiabetic effects of S-allyl cysteine sulphoxide isolated from garlic Allium sativum Linn.

C G Sheela1, K T Augusti.   

Abstract

S-allyl cysteine sulphoxide (SACS), a sulphur containing amino acid of garlic which is the precursor of allicin and garlic oil, has been found to show significant antidiabetic effects in alloxan diabetic rats. Administration of it at a dose of 200 mg/kg body weight decreased significantly the concentration of serum lipids, blood glucose and activities of serum enzymes like alkaline phosphatase, acid phosphatase and lactate dehydrogenase and liver glucose-6-phosphatase. It increased significantly liver and intestinal HMG CoA reductase activity and liver hexokinase activity.

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Year:  1992        PMID: 1506036

Source DB:  PubMed          Journal:  Indian J Exp Biol        ISSN: 0019-5189            Impact factor:   0.818


  32 in total

Review 1.  Prevention of non-enzymatic glycosylation (glycation): Implication in the treatment of diabetic complication.

Authors:  H Younus; S Anwar
Journal:  Int J Health Sci (Qassim)       Date:  2016-04

Review 2.  A review on the effects of Allium sativum (Garlic) in metabolic syndrome.

Authors:  A Hosseini; H Hosseinzadeh
Journal:  J Endocrinol Invest       Date:  2015-06-03       Impact factor: 4.256

3.  A rethinking on the benefits and drawbacks of common antioxidants and a proposal to look for the antioxidants in allium products as ideal agents: a review.

Authors:  K T Augusti; Regi Jose; G R Sajitha; Paul Augustine
Journal:  Indian J Clin Biochem       Date:  2011-08-09

4.  Phytochemical profiling and bioactivity of a mangrove plant, Sonneratia apetala, from Odisha Coast of India.

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Journal:  Chin J Integr Med       Date:  2014-09-24       Impact factor: 1.978

5.  Beneficial protective effects of 2-allyl amino 4-methyl sulfanyl butyric acid on glucose metabolism and glycoprotein components in streptozotocin induced diabetic rats with molecular modeling.

Authors:  K Balan; P Pratheebaa; T Jebastin; N Sundarabaalaji; Xiuhua Liu; T Palvannan
Journal:  Toxicol Res (Camb)       Date:  2015-11-18       Impact factor: 3.524

6.  Allicin ameliorates obesity comorbid depressive-like behaviors: involvement of the oxidative stress, mitochondrial function, autophagy, insulin resistance and NOX/Nrf2 imbalance in mice.

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Journal:  Metab Brain Dis       Date:  2019-06-14       Impact factor: 3.584

Review 7.  Mechanism of action of natural products used in the treatment of diabetes mellitus.

Authors:  Pranav Kumar Prabhakar; Mukesh Doble
Journal:  Chin J Integr Med       Date:  2011-08-09       Impact factor: 1.978

8.  In vivo assessment of antihyperglycemic and antioxidant activity from oil of seeds of brassica nigra in streptozotocin induced diabetic rats.

Authors:  Manoj Kumar; Sunil Sharma; Neeru Vasudeva
Journal:  Adv Pharm Bull       Date:  2013-08-20

9.  Histopathological findings of the pancreas, liver, and carbohydrate metabolizing enzymes in STZ-induced diabetic rats improved by administration of myrtenal.

Authors:  Ayyasamy Rathinam; Leelavinothan Pari; Ramasamy Chandramohan; Bashir Ahmad Sheikh
Journal:  J Physiol Biochem       Date:  2014-10-08       Impact factor: 4.158

10.  Effects of sodium-orthovanadate and Trigonella foenum-graecum seeds on hepatic and renal lipogenic enzymes and lipid profile during alloxan diabetes.

Authors:  Umesh C S Yadav; K Moorthy; Najma Z Baquer
Journal:  J Biosci       Date:  2004-03       Impact factor: 1.826

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