Literature DB >> 15060051

PhoP can activate its target genes in a PhoQ-independent manner.

Sergio Lejona1, María Eugenia Castelli, María Laura Cabeza, Linda J Kenney, Eleonora García Véscovi, Fernando C Soncini.   

Abstract

The PhoP/PhoQ two-component system controls the extracellular magnesium depletion response in Salmonella enterica. Previous studies have shown that PhoP is unable to up-regulate its target genes in the absence of PhoQ function. In this work, we demonstrate that PhoP overexpression can substitute for PhoQ- and phosphorylation-dependent activation. Either a high concentration of PhoP or activation via phosphorylation stimulates PhoP self-association.

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Year:  2004        PMID： 15060051      PMCID： PMC412160          DOI： 10.1128/JB.186.8.2476-2480.2004

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  27 in total

1.  Phosphorylation-induced dimerization of the FixJ receiver domain.

Authors:  S Da Re; J Schumacher; P Rousseau; J Fourment; C Ebel; D Kahn
Journal:  Mol Microbiol       Date:  1999-11       Impact factor: 3.501

Review 2.  The pleiotropic two-component regulatory system PhoP-PhoQ.

Authors:  E A Groisman
Journal:  J Bacteriol       Date:  2001-03       Impact factor: 3.490

3.  The unphosphorylated receiver domain of PhoB silences the activity of its output domain.

Authors:  D W Ellison; W R McCleary
Journal:  J Bacteriol       Date:  2000-12       Impact factor: 3.490

4.  Tandem DNA recognition by PhoB, a two-component signal transduction transcriptional activator.

Authors:  Alexandre G Blanco; Maria Sola; F Xavier Gomis-Rüth; Miquel Coll
Journal:  Structure       Date:  2002-05       Impact factor: 5.006

5.  Residue R113 is essential for PhoP dimerization and function: a residue buried in the asymmetric PhoP dimer interface determined in the PhoPN three-dimensional crystal structure.

Authors:  Yinghua Chen; Catherine Birck; Jean-Pierre Samama; F Marion Hulett
Journal:  J Bacteriol       Date:  2003-01       Impact factor: 3.490

6.  Relative binding affinities of OmpR and OmpR-phosphate at the ompF and ompC regulatory sites.

Authors:  C G Head; A Tardy; L J Kenney
Journal:  J Mol Biol       Date:  1998-09-04       Impact factor: 5.469

7.  The phosphatase activity is the target for Mg2+ regulation of the sensor protein PhoQ in Salmonella.

Authors:  M E Castelli; E García Véscovi; F C Soncini
Journal:  J Biol Chem       Date:  2000-07-28       Impact factor: 5.157

8.  Phosphorylated PmrA interacts with the promoter region of ugd in Salmonella enterica serovar typhimurium.

Authors:  A Aguirre; S Lejona; E G Véscovi; F C Soncini
Journal:  J Bacteriol       Date:  2000-07       Impact factor: 3.490

9.  Multimerization of phosphorylated and non-phosphorylated ArcA is necessary for the response regulator function of the Arc two-component signal transduction system.

Authors:  Y Jeon; Y S Lee; J S Han; J B Kim; D S Hwang
Journal:  J Biol Chem       Date:  2001-08-29       Impact factor: 5.157

10.  Phosphorylation-induced signal propagation in the response regulator ntrC.

Authors:  J Lee; J T Owens; I Hwang; C Meares; S Kustu
Journal:  J Bacteriol       Date:  2000-09       Impact factor: 3.490
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  32 in total

1.  Regulatory Effect of SlyA on rcsB Expression in Salmonella enterica Serovar Typhimurium.

Authors:  María F Ballesteros; Mónica F Torrez Lamberti; Juan V Farizano; María M Pescaretti; Mónica A Delgado
Journal:  J Bacteriol       Date:  2019-01-28       Impact factor: 3.490

2.  SrfJ, a Salmonella type III secretion system effector regulated by PhoP, RcsB, and IolR.

Authors:  Mar Cordero-Alba; Joaquín Bernal-Bayard; Francisco Ramos-Morales
Journal:  J Bacteriol       Date:  2012-06-01       Impact factor: 3.490

3.  Phosphorylation of PhoP protein plays direct regulatory role in lipid biosynthesis of Mycobacterium tuberculosis.

Authors:  Rajni Goyal; Arijit Kumar Das; Ranjeet Singh; Pradip K Singh; Suresh Korpole; Dibyendu Sarkar
Journal:  J Biol Chem       Date:  2011-11-09       Impact factor: 5.157

4.  Domain structure of virulence-associated response regulator PhoP of Mycobacterium tuberculosis: role of the linker region in regulator-promoter interaction(s).

Authors:  Anuj Pathak; Rajni Goyal; Akesh Sinha; Dibyendu Sarkar
Journal:  J Biol Chem       Date:  2010-09-02       Impact factor: 5.157

5.  Characterization of phagosome trafficking and identification of PhoP-regulated genes important for survival of Yersinia pestis in macrophages.

Authors:  Jens P Grabenstein; Hana S Fukuto; Lance E Palmer; James B Bliska
Journal:  Infect Immun       Date:  2006-07       Impact factor: 3.441

6.  Discovery of novel secreted virulence factors from Salmonella enterica serovar Typhimurium by proteomic analysis of culture supernatants.

Authors:  George S Niemann; Roslyn N Brown; Jean K Gustin; Afke Stufkens; Afshan S Shaikh-Kidwai; Jie Li; Jason E McDermott; Heather M Brewer; Athena Schepmoes; Richard D Smith; Joshua N Adkins; Fred Heffron
Journal:  Infect Immun       Date:  2010-10-25       Impact factor: 3.441

7.  PhoP-PhoP interaction at adjacent PhoP binding sites is influenced by protein phosphorylation.

Authors:  Akesh Sinha; Sankalp Gupta; Shweta Bhutani; Anuj Pathak; Dibyendu Sarkar
Journal:  J Bacteriol       Date:  2007-12-07       Impact factor: 3.490

8.  CtrA, a global response regulator, uses a distinct second category of weak DNA binding sites for cell cycle transcription control in Caulobacter crescentus.

Authors:  William Spencer; Rania Siam; Marie-Claude Ouimet; D Patrick Bastedo; Gregory T Marczynski
Journal:  J Bacteriol       Date:  2009-06-19       Impact factor: 3.490

9.  Molecular mechanism for establishment of signal-dependent regulation in the PhoP/PhoQ system.

Authors:  Wei Kong; Natasha Weatherspoon; Yixin Shi
Journal:  J Biol Chem       Date:  2008-04-22       Impact factor: 5.157

10.  The atypical response regulator protein ChxR has structural characteristics and dimer interface interactions that are unique within the OmpR/PhoB subfamily.

Authors:  John M Hickey; Scott Lovell; Kevin P Battaile; Lei Hu; C Russell Middaugh; P Scott Hefty
Journal:  J Biol Chem       Date:  2011-07-20       Impact factor: 5.157
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