| Literature DB >> 15059185 |
Antonella Muraro1, Sten Dreborg, Susanne Halken, Arne Høst, Bodo Niggemann, Rob Aalberse, Syed H Arshad, Andrea von Berg Av, Kai- Hå kon Carlsen, Karel Duschén, Philippe Eigenmann, David Hill, Catherine Jones, Michael Mellon, Göran Oldeus, Arnold Oranje, Cristina Pascual, Susan Prescott, Hugh Sampson, Magnus Svartengren, Yvan Vandenplas, Ulrich Wahn, Jill A Warner, John O Warner, Magnus Wickman, Robert S Zeiger.
Abstract
The role of primary prevention of allergic diseases has been a matter of debate for the last 40 years. In order to shed some light into this issue, a group of experts of the Section of Pediatrics EAACI critically reviewed the existing literature on the subject. In this paper, the immunology of the fetus and newborn is reviewed as well as the post-natal development of the immune system. The influence of post-natal environment and breastfeeding on tolerance induction and sensitization are examined. Allergic diseases result from a strong relationship between genetic and environmental factors. Sensitization to food allergens occurs in the first year of life and cow's milk allergy is the first food allergy to appear in the susceptible infants. Hypoallergenicity of food formulas to be used is a critical issue both for treatment of cow's milk-allergic children and for prevention. Methods to document hypoallergenicity are discussed and evaluated in the preclinical and clinical steps.Entities:
Mesh：
Year: 2004 PMID： 15059185 DOI： 10.1046/j.1399-3038.2003.00129.x
Source DB: PubMed Journal: Pediatr Allergy Immunol ISSN： 0905-6157 Impact factor: 6.377