Literature DB >> 1505886

Screening for a new generation of anthelminthic compounds. In vitro selection of the nematode Caenorhabditis elegans for ivermectin resistance.

J Novák1, Z Vanĕk.   

Abstract

Development of resistance to ivermectin in vitro is reported for the first time. Two strains of Caenorhabditis elegans D5 and D6 able to grow on agar plates after treating with up to 3 mg ivermectin per L were selected. The parent strain N2 was extremely sensitive to ivermectin, its growth being inhibited by treatment with 0.1-0.2 mg IVM per L.

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Year:  1992        PMID： 1505886     DOI： 10.1007/bf02933156

Source DB:  PubMed          Journal:  Folia Microbiol (Praha)        ISSN： 0015-5632            Impact factor:   2.099


  4 in total

1.  Ivermectin: an update.

Authors:  W C Campbell
Journal:  Parasitol Today       Date:  1985-07

2.  Laboratory selection of a benzimidazole-resistant isolate of Trichostrongylus colubriformis for ivermectin resistance.

Authors:  W L Shoop; J R Egerton; C H Eary; D Suhayda
Journal:  J Parasitol       Date:  1990-04       Impact factor: 1.276

Review 3.  Philosophy of new drug discovery.

Authors:  S Omura
Journal:  Microbiol Rev       Date:  1986-09

4.  The genetics of Caenorhabditis elegans.

Authors:  S Brenner
Journal:  Genetics       Date:  1974-05       Impact factor: 4.562
  4 in total
  2 in total

1.  Pharmacological maintenance of protein homeostasis could postpone age-related disease.

Authors:  Silvestre Alavez; Gordon J Lithgow
Journal:  Aging Cell       Date:  2012-02-01       Impact factor: 9.304

Review 2.  Curcumin and neurodegenerative diseases.

Authors:  Adriana Monroy; Gordon J Lithgow; Silvestre Alavez
Journal:  Biofactors       Date:  2013-01-10       Impact factor: 6.113
  2 in total

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