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Literature DB >> 15057887

Host factors and failure of interferon-alpha treatment in hepatitis C virus.

Abstract

Failure of interferon-alpha (IFN-alpha) treatment in patients with chronic hepatitis C virus (HCV) infection is a challenging obstacle for clinical and experimental hepatology. Both viral and host factors have been implicated in reducing responsiveness to IFN-alpha therapy. The role of viral factors has been studied extensively and has been summarized in several review articles; however, much less attention has been paid to host factors. In this paper, we review evidence of host factor involvement in IFN-alpha treatment failure. We discuss possible underlying mechanisms responsible for these effects. Potential therapeutic strategies to enhance the effectiveness of IFN-alpha therapy for HCV are also proposed.

Entities: Disease Gene Species

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Year: 2004 PMID： 15057887 DOI： 10.1002/hep.20139

Source DB: PubMed Journal: Hepatology ISSN： 0270-9139 Impact factor: 17.425

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Cited

55 in total

1. Identification of treatment efficacy-related host factors in chronic hepatitis C by ProteinChip serum analysis.

Authors: Naoki Fujita; Mamoru Nakanishi; Jun Mukai; Yuuji Naito; Takafumi Ichida; Masahiko Kaito; Toshikazu Yoshikawa; Yoshiyuki Takei
Journal: Mol Med Date: 2010-10-05 Impact factor: 6.354

2. Mutations around interferon sensitivity-determining region: a pilot resistance report of hepatitis C virus 1b in a Hong Kong population.

Authors: Xiao-Ming Zhou; Paul Ks Chan; John S Tam
Journal: World J Gastroenterol Date: 2011-12-28 Impact factor: 5.742

3. Association of pretreatment serum interferon gamma inducible protein 10 levels with sustained virological response to peginterferon plus ribavirin therapy in genotype 1 infected patients with chronic hepatitis C.

Authors: M Diago; G Castellano; J García-Samaniego; C Pérez; I Fernández; M Romero; O L Iacono; C García-Monzón
Journal: Gut Date: 2005-09-08 Impact factor: 23.059

Review 4. Mechanisms of HCV survival in the host.

Authors: Ella H Sklan; Prista Charuworn; Philip S Pang; Jeffrey S Glenn
Journal: Nat Rev Gastroenterol Hepatol Date: 2009-04 Impact factor: 46.802

5. Genetic variants in chemokine CC subfamily genes influence hepatitis C virus viral clearance.

Authors: Yinan Yao; Ming Yue; Feng Zang; Mei Liu; Haozhi Fan; Lingyun Zhuo; Jingjing Wu; Xueshan Xia; Yue Feng; Peng Huang; Rongbin Yu
Journal: J Hum Genet Date: 2018-04-27 Impact factor: 3.172

6. Association of single nucleotide polymorphisms in interferon signaling pathway genes and interferon-stimulated genes with the response to interferon therapy for chronic hepatitis C.

Authors: Xiaowen Su; Leland J Yee; KyungAh Im; Shannon L Rhodes; YongMing Tang; Xiaomei Tong; Charles Howell; Darmendra Ramcharran; Hugo R Rosen; Milton W Taylor; T Jake Liang; Huiying Yang
Journal: J Hepatol Date: 2008-05-20 Impact factor: 25.083

7. Non-response to antiviral therapy is associated with obesity and increased hepatic expression of suppressor of cytokine signalling 3 (SOCS-3) in patients with chronic hepatitis C, viral genotype 1.

Authors: M J Walsh; J R Jonsson; M M Richardson; G M Lipka; D M Purdie; A D Clouston; E E Powell
Journal: Gut Date: 2005-11-18 Impact factor: 23.059