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Literature DB >> 1505760

Treatment of persistent epithelial defects in neurotrophic keratitis with epidermal growth factor: a preliminary open study.

Abstract

We report three patients with persistent epithelial defects in the context of neurotrophic keratopathy that healed while on treatment with topically applied, mouse-derived epidermal growth factor (m-EGF). The clinical course of these patients was striking and suggests that EGF may have a potential role in the treatment of persistent epithelial defects in subjects suffering from neurotrophic keratitis.

Entities: Disease Gene Species

Mesh：

Substances：
Epidermal Growth Factor

Year: 1992 PMID： 1505760 DOI： 10.1007/bf00165937

Source DB: PubMed Journal: Graefes Arch Clin Exp Ophthalmol ISSN： 0721-832X Impact factor: 3.117

12 in total

1. The stimulation of epidermal keratinization by a protein isolated from the submaxillary gland of the mouse.

Authors: S COHEN; G A ELLIOTT
Journal: J Invest Dermatol Date: 1963-01 Impact factor: 8.551

2. Mitotic and wound-healing activities of the corneal epithelium; effect of sensory denervation.

Authors: S SIGELMAN; J S FRIEDENWALD
Journal: AMA Arch Ophthalmol Date: 1954-07

Review 3. Prospects for epidermal growth factor in the management of corneal disorders.

Authors: R C Tripathi; S C Raja; B J Tripathi
Journal: Surv Ophthalmol Date: 1990 May-Jun Impact factor: 6.048

4. Tear film and ocular surface changes in a rabbit model of neurotrophic keratitis.

Authors: J P Gilbard; S R Rossi
Journal: Ophthalmology Date: 1990-03 Impact factor: 12.079

5. Effect of topically administered epidermal growth factor on corneal wound strength.

Authors: H M Leibowitz; S Morello; M Stern; A Kupferman
Journal: Arch Ophthalmol Date: 1990-05

6. Presence of epidermal growth factor in human tears.

Authors: Y Ohashi; M Motokura; Y Kinoshita; T Mano; H Watanabe; S Kinoshita; R Manabe; K Oshiden; C Yanaihara
Journal: Invest Ophthalmol Vis Sci Date: 1989-08 Impact factor: 4.799

7. Epidermal growth factor is a constant component of normal human tear fluid.

Authors: G B van Setten; L Viinikka; T Tervo; K Pesonen; A Tarkkanen; J Perheentupa
Journal: Graefes Arch Clin Exp Ophthalmol Date: 1989 Impact factor: 3.117

8. Selective binding of the epidermal growth factor and its specific effects on the epithelial cells of the cornea.

Authors: L Frati; S Daniele; A Delogu; I Covelli
Journal: Exp Eye Res Date: 1972-09 Impact factor: 3.467

Review 9. The epidermal growth factor (EGF).

Authors: S Cohen
Journal: Cancer Date: 1983-05-15 Impact factor: 6.860

Treatment of persistent epithelial defects in neurotrophic keratitis with epidermal growth factor: a preliminary open study.

1. The stimulation of epidermal keratinization by a protein isolated from the submaxillary gland of the mouse.

2. Mitotic and wound-healing activities of the corneal epithelium; effect of sensory denervation.

Review 3. Prospects for epidermal growth factor in the management of corneal disorders.

4. Tear film and ocular surface changes in a rabbit model of neurotrophic keratitis.

5. Effect of topically administered epidermal growth factor on corneal wound strength.

6. Presence of epidermal growth factor in human tears.

7. Epidermal growth factor is a constant component of normal human tear fluid.

8. Selective binding of the epidermal growth factor and its specific effects on the epithelial cells of the cornea.

Review 9. The epidermal growth factor (EGF).

10. The effect of the epidermal growth factor (EGF) on the corneal epithelium in humans.

Review 1. Diagnosis and management of neurotrophic keratitis.

2. Pigment Epithelium-Derived Factor Peptide Promotes Corneal Nerve Regeneration: An In Vivo and In Vitro Study.

Review 3. Plasmacytoid dendritic cells in the eye.

Review 4. Neurotrophic factors and corneal nerve regeneration.

5. Effect of epidermal growth factor ointment on persistent epithelial defects of the cornea.