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Literature DB >> 15057299

The beta1 subunit of the Ca2+-sensitive K+ channel protects against hypertension.

Abstract

Previous animal studies have demonstrated that the loss of the beta(1) subunit of the large-conductance Ca(2+)-activated K(+) (BK) channel leads to hypertension. A new study demonstrates that a gain in beta(1) subunit function is associated with protection against diastolic hypertension in humans, underscoring the importance of the beta(1) subunit and the BK channel in the regulation of vascular resistance.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2004 PMID： 15057299 PMCID： PMC379328 DOI： 10.1172/JCI21388

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

27 in total

Review 1. Calcium sparks in smooth muscle.

Authors: J H Jaggar; V A Porter; W J Lederer; M T Nelson
Journal: Am J Physiol Cell Physiol Date: 2000-02 Impact factor: 4.249

Review 2. Molecular mechanisms of human hypertension.

Authors: R P Lifton; A G Gharavi; D S Geller
Journal: Cell Date: 2001-02-23 Impact factor: 41.582

3. Mice with disrupted BK channel beta1 subunit gene feature abnormal Ca(2+) spark/STOC coupling and elevated blood pressure.

Authors: S Plüger; J Faulhaber; M Fürstenau; M Löhn; R Waldschütz; M Gollasch; H Haller; F C Luft; H Ehmke; O Pongs
Journal: Circ Res Date: 2000-11-24 Impact factor: 17.367

4. Vasoregulation by the beta1 subunit of the calcium-activated potassium channel.

Authors: R Brenner; G J Peréz; A D Bonev; D M Eckman; J C Kosek; S W Wiler; A J Patterson; M T Nelson; R W Aldrich
Journal: Nature Date: 2000-10-19 Impact factor: 49.962

5. The BK channel beta1 subunit gene is associated with human baroreflex and blood pressure regulation.

Authors: Maik Gollasch; Jens Tank; Friedrich C Luft; Jens Jordan; Philipp Maass; Christine Krasko; Arya M Sharma; Andreas Busjahn; Sylvia Bähring
Journal: J Hypertens Date: 2002-05 Impact factor: 4.844

6. Role of the beta1 subunit in large-conductance Ca(2+)-activated K(+) channel gating energetics. Mechanisms of enhanced Ca(2+) sensitivity.

Authors: D H Cox; R W Aldrich
Journal: J Gen Physiol Date: 2000-09 Impact factor: 4.086

7. Acute activation of Maxi-K channels (hSlo) by estradiol binding to the beta subunit.

Authors: M A Valverde; P Rojas; J Amigo; D Cosmelli; P Orio; M I Bahamonde; G E Mann; C Vergara; R Latorre
Journal: Science Date: 1999-09-17 Impact factor: 47.728

8. Spontaneous transient outward currents arise from microdomains where BK channels are exposed to a mean Ca(2+) concentration on the order of 10 microM during a Ca(2+) spark.

Authors: Ronghua Zhuge; Kevin E Fogarty; Richard A Tuft; John V Walsh
Journal: J Gen Physiol Date: 2002-07 Impact factor: 4.086

9. Coupling between voltage sensor activation, Ca2+ binding and channel opening in large conductance (BK) potassium channels.

Authors: Frank T Horrigan; Richard W Aldrich
Journal: J Gen Physiol Date: 2002-09 Impact factor: 4.086

Review 10. Rising behind NO: cGMP-dependent protein kinases.

Authors: F Hofmann; A Ammendola; J Schlossmann
Journal: J Cell Sci Date: 2000-05 Impact factor: 5.285

17 in total

1. CDK5 interacts with Slo and affects its surface expression and kinetics through direct phosphorylation.

Authors: Jun-Ping Bai; Alexei Surguchev; Powrnima Joshi; Liza Gross; Dhasakumar Navaratnam
Journal: Am J Physiol Cell Physiol Date: 2011-11-16 Impact factor: 4.249

2. Hair cell BK channels interact with RACK1, and PKC increases its expression on the cell surface by indirect phosphorylation.

Authors: Alexei Surguchev; Jun-Ping Bai; Powrnima Joshi; Dhasakumar Navaratnam
Journal: Am J Physiol Cell Physiol Date: 2012-04-25 Impact factor: 4.249

Review 3. Transduction of voltage and Ca2+ signals by Slo1 BK channels.

Authors: T Hoshi; A Pantazis; R Olcese
Journal: Physiology (Bethesda) Date: 2013-05

Review 4. Mechanisms of Vascular Smooth Muscle Contraction and the Basis for Pharmacologic Treatment of Smooth Muscle Disorders.

Authors: F V Brozovich; C J Nicholson; C V Degen; Yuan Z Gao; M Aggarwal; K G Morgan
Journal: Pharmacol Rev Date: 2016-04 Impact factor: 25.468

5. β4-subunit increases Slo responsiveness to physiological Ca2+ concentrations and together with β1 reduces surface expression of Slo in hair cells.

Authors: Jun-Ping Bai; Alexei Surguchev; Dhasakumar Navaratnam
Journal: Am J Physiol Cell Physiol Date: 2010-12-22 Impact factor: 4.249

Review 6. Oxidative modulation of voltage-gated potassium channels.

Authors: Nirakar Sahoo; Toshinori Hoshi; Stefan H Heinemann
Journal: Antioxid Redox Signal Date: 2013-10-26 Impact factor: 8.401

7. Molecular cloning, tissue distribution and bioinformatics analyses of the rabbit BK channel beta1 subunit gene.

Authors: Xiao-Yong Zhang; Sha Wang; Zhen Yan; Yi Wan; Wei Wang; Guang-Bin Cui; Pang Du; Ke-Jun Ma; Wei Han; Ying-Qi Zhang; Jing-Guo Wei
Journal: Mol Biol Rep Date: 2007-09-14 Impact factor: 2.316

8. Mechanism of the modulation of BK potassium channel complexes with different auxiliary subunit compositions by the omega-3 fatty acid DHA.

Authors: Toshinori Hoshi; Yutao Tian; Rong Xu; Stefan H Heinemann; Shangwei Hou
Journal: Proc Natl Acad Sci U S A Date: 2013-03-04 Impact factor: 11.205

9. Omega-3 fatty acids lower blood pressure by directly activating large-conductance Ca²⁺-dependent K⁺ channels.

Authors: Toshinori Hoshi; Bianka Wissuwa; Yutao Tian; Nobuyoshi Tajima; Rong Xu; Michael Bauer; Stefan H Heinemann; Shangwei Hou
Journal: Proc Natl Acad Sci U S A Date: 2013-03-04 Impact factor: 11.205

Review 10. Interacting influence of diuretics and diet on BK channel-regulated K homeostasis.

Authors: Donghai Wen; Ryan J Cornelius; Steven C Sansom
Journal: Curr Opin Pharmacol Date: 2013-12-11 Impact factor: 5.547