| Literature DB >> 15049108 |
Lauro Ferreira da Silva Pinto Neto1, Nilo F Vieira, Moacir Soprani, Carla B Cunha, Valéria P Cabral, Reynaldo Dietze, Rodrigo Ribeiro-Rodrigues.
Abstract
This study was designed to investigate the impact of anti-retroviral therapy on both plasma and seminal HIV-1 viral loads and the correlation between viral loads in these compartments after treatment. Viral load, CD4+ and CD8+ T-cell counts were evaluated in paired plasma and semen samples from 36 antiretroviral therapy-naive patients at baseline and on days 45, 90, and 180 of treatment. Slopes for blood and seminal viral loads in all treated patients were similar (p = 0.21). Median HIV-1 RNA titers in plasma and semen at baseline were 4.95 log10 and 4.48 log10 copies/ml, respectively. After 180 days of therapy, the median viral load declined to 3.15 log10 copies/ml (plasma) and 3.2 log10 copies/ml (semen). At this timepoint 22 patients presented HIV-1 viral load below 400 copies/ml in either plasma or semen, but only 9 had viral loads below 400 copies/ml in both compartments.Entities:
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Year: 2004 PMID： 15049108 DOI： 10.1590/s0037-86822003000600008
Source DB: PubMed Journal: Rev Soc Bras Med Trop ISSN： 0037-8682 Impact factor: 1.581