| Literature DB >> 1504836 |
M Sawada1, A Suzumura, T Marunouchi.
Abstract
Astrocytes and microglia, both produced interleukin-6 (IL-6) in culture by lipopolysaccharide (LPS) stimulation. IL-6 activity was detected 3-5 h after LPS stimulation and reached a maximum at 10 h. Microglia responded faster than astrocytes. Tumor necrosis factor alpha and interleukin 1 also induced IL-6 mRNA and biological activity in astrocytes, but not in microglia. Among these stimuli, LPS was the most potent inducer of IL-6 production by astrocytes. Our results suggest that different regulatory mechanisms for cytokine production exist in glial cells. The possible roles of astrocytes and microglia in CNS immune responses are also discussed.Entities:
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Year: 1992 PMID： 1504836 DOI： 10.1016/s0006-8993(10)80037-x
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252