| Literature DB >> 19214748 |
Kerly Wollmeister Hofmann1, Artur Francisco Schumacher Schuh, Jonas Saute, Raquel Townsend, Daniele Fricke, Renata Leke, Diogo O Souza, Luis Valmor Portela, Márcia Lorena Fagundes Chaves, Carlos R M Rieder.
Abstract
Several lines of evidence suggest that neuroimmune mechanisms may be involved in the neurodegenerative process of Parkinson's disease (PD). Interleukin-6 (IL-6) is increased in the nigrostriatal region and in the cerebrospinal fluid of patients with PD. IL-6 serum level was evaluated in PD patients. The effects of levodopa treatment and disease severity on IL-6 were also studied. The IL-6 levels were similar between PD patients (treated and not treated) and controls. However, there was a negative correlation of IL-6 levels and the activities of daily living scale (P < 0.05), indicating that patients with more severe disease have higher levels of this cytokine. No correlation involving levodopa treatment and IL-6 serum level was found. The results suggest that only marginal effects of IL-6 occur on the peripheral immune system, and that the role of IL-6 and others neuroimmune factors needs to be well elucidated on PD.Entities:
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Year: 2009 PMID： 19214748 DOI： 10.1007/s11064-009-9921-z
Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996