G C Jagetia1, G K Rajanikant. 1. Department of Radiobiology, Kasturba Medical College, Manipal, India. gc.jagetia@kmc.manipal.edu
Abstract
OBJECTIVE: To study the effect on wound contraction of pretreatment with various doses of curcumin (the most important active ingredient of the spice turmeric) in mice exposed to 6 Gy whole-body gamma radiation. METHOD: A full-thickness skin wound was produced on the dorsum of Swiss albino mice treated with and without 25, 50, 100, 150 or 200 mg/kg body weight of curcumin before exposure to 6 Gy gamma radiation. Progression of wound contraction was monitored using video images of the wound at various days post-irradiation until full healing occurred. Mean wound healing times were also calculated. RESULTS: Irradiation caused significant delay in wound contraction and healing times. However, treatment with curcumin resulted in a dose-dependent increase in contraction when compared with a control. Greatest contraction was observed for 100 mg/kg curcumin, with statistically significant results at days three (p < 0.009), six (p < 0.05) and nine (p < 0.05) post-irradiation for this dose. Complete healing was achieved by day 23 post-irradiation in the curcumin-treated irradiation group. CONCLUSION: Pretreatment with curcumin has a conductive effect on irradiated wounds. It could be a substantial therapeutic agent for ameliorating radiation-induced delay in wound repair in cases of combined injuries.
OBJECTIVE: To study the effect on wound contraction of pretreatment with various doses of curcumin (the most important active ingredient of the spice turmeric) in mice exposed to 6 Gy whole-body gamma radiation. METHOD: A full-thickness skin wound was produced on the dorsum of Swiss albino mice treated with and without 25, 50, 100, 150 or 200 mg/kg body weight of curcumin before exposure to 6 Gy gamma radiation. Progression of wound contraction was monitored using video images of the wound at various days post-irradiation until full healing occurred. Mean wound healing times were also calculated. RESULTS: Irradiation caused significant delay in wound contraction and healing times. However, treatment with curcumin resulted in a dose-dependent increase in contraction when compared with a control. Greatest contraction was observed for 100 mg/kg curcumin, with statistically significant results at days three (p < 0.009), six (p < 0.05) and nine (p < 0.05) post-irradiation for this dose. Complete healing was achieved by day 23 post-irradiation in the curcumin-treated irradiation group. CONCLUSION: Pretreatment with curcumin has a conductive effect on irradiated wounds. It could be a substantial therapeutic agent for ameliorating radiation-induced delay in wound repair in cases of combined injuries.
Authors: P L Palatty; A Azmidah; S Rao; D Jayachander; K R Thilakchand; M P Rai; R Haniadka; P Simon; R Ravi; R Jimmy; P F D'souza; R Fayad; M S Baliga Journal: Br J Radiol Date: 2014-04-02 Impact factor: 3.039
Authors: Mustafa Kulac; Cevat Aktas; Feti Tulubas; Ramazan Uygur; Mehmet Kanter; Mustafa Erboga; Mehmet Ceber; Birol Topcu; Oguz Aslan Ozen Journal: J Mol Histol Date: 2012-10-02 Impact factor: 2.611