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Literature DB >> 18081782

Radiotherapy and wound healing.

Abstract

This review article discusses basic radiation physics and effects of radiation on wounds. It examines various postulated hypothesis on the role of circulatory decrease and radiation-induced direct cellular damage. The new concept related to the radiation pathogenesis proposes that there is a cascade of cytokines initiated immediately after the radiation. Sustained activation of myofibroblasts in the wound accounts for its chronicity. Recent advances highlight that transforming growth factor beta1 is the master switch in pathogenesis of radiation fibrosis. This articles overviews its role and summarises the available evidences related to radiation damage. The goal of this article was to provide its modern understanding, as future research will concentrate on antagonising the effects of cytokines to promote wound healing.

Entities: Disease Gene

Mesh：

Substances：
Cytokines

Year: 2007 PMID： 18081782 PMCID： PMC7951499 DOI： 10.1111/j.1742-481X.2007.00351.x

Source DB: PubMed Journal: Int Wound J ISSN： 1742-4801 Impact factor: 3.315

30 in total

1. A study on the activity of fibroblast cells in connection with tissue recovery in the wounds of skin injury after whole-body irradiation.

Authors: Jifu Qu; Tianmin Cheng; Chunmeng Shi; Yuan Lin; Xinze Ran
Journal: J Radiat Res Date: 2004-06 Impact factor: 2.724

2. The effects of total-body irradiation on the survival and skin wound healing of rats with combined radiation-wound injury.

Authors: Xinze Ran; Tianmin Cheng; Chunmeng Shi; Hui Xu; Jifu Qu; Guohe Yan; Yongping Su; Wenchang Wang; Rufu Xu
Journal: J Trauma Date: 2004-11

Review 3. TGF-beta1 and radiation fibrosis: a master switch and a specific therapeutic target?

Authors: M Martin; J Lefaix; S Delanian
Journal: Int J Radiat Oncol Biol Phys Date: 2000-05-01 Impact factor: 7.038

Review 4. Transforming growth factor beta in tissue fibrosis.

Authors: W A Border; N A Noble
Journal: N Engl J Med Date: 1994-11-10 Impact factor: 91.245

5. Primary rectus abdominis myocutaneous flap for repair of perineal and vaginal defects after extended abdominoperineal resection.

Authors: S W Bell; N Dehni; M Chaouat; J C Lifante; R Parc; E Tiret
Journal: Br J Surg Date: 2005-04 Impact factor: 6.939

6. The effect of pre-operative conventional and hyperfractionated radiotherapy schedules on wound healing and tensile strength in rats: an experimental study.

Authors: N Ozbek; E Guneren; L Yildiz; D Meydan; S Cakir; M Coskun
Journal: Int J Oral Maxillofac Surg Date: 2005-03 Impact factor: 2.789

7. The ultrastructure and etiology of chronic radiotherapy damage in human skin.

Authors: R Rudolph; T Arganese; M Woodward
Journal: Ann Plast Surg Date: 1982-10 Impact factor: 1.539

8. Radiation-induced changes in skin type I and III collagen synthesis during and after conventionally fractionated radiotherapy.

Authors: Riitta Keskikuru; Arja Jukkola; Jouni Nuutinen; Vesa Kataja; Juha Risteli; Pekka Autio; Tapani Lahtinen
Journal: Radiother Oncol Date: 2004-03 Impact factor: 6.280

9. Antitumor histone deacetylase inhibitors suppress cutaneous radiation syndrome: Implications for increasing therapeutic gain in cancer radiotherapy.

Authors: Yih Lin Chung; Ae-June Wang; Lin-Fen Yao
Journal: Mol Cancer Ther Date: 2004-03 Impact factor: 6.261

10. Normal transcutaneous oxygen pressure in skin after radiation therapy for cancer.

Authors: R Rudolph; P Tripuraneni; J A Koziol; M McKean-Matthews; A Frutos
Journal: Cancer Date: 1994-12-01 Impact factor: 6.860

15 in total

1. Radiochemotherapy-induced reactivation of scar tissue on ¹⁸F-FDG PET/CT.

Authors: Axel Van Damme; Fréderic Duprez; Peter Tomassen; David Creytens; Ingeborg Goethals
Journal: Eur J Nucl Med Mol Imaging Date: 2018-08-11 Impact factor: 9.236

2. microRNA alterations driving acute and late stages of radiation-induced fibrosis in a murine skin model.

Authors: Brittany A Simone; David Ly; Jason E Savage; Stephen M Hewitt; Tu D Dan; Kris Ylaya; Uma Shankavaram; Meng Lim; Lianjin Jin; Kevin Camphausen; James B Mitchell; Nicole L Simone
Journal: Int J Radiat Oncol Biol Phys Date: 2014-06-28 Impact factor: 7.038

3. Nutritional status of patients referred for hyperbaric oxygen treatment; a retrospective and descriptive cross-sectional study.

Authors: Rutger C Lalieu; Ida Akkerman; Peter-Jan Am van Ooij; Annieke A Boersma-Voogd; Rob A van Hulst
Journal: Diving Hyperb Med Date: 2021-12-20 Impact factor: 0.887

4. Design and Synthesis of a Mitochondria-Targeting Radioprotectant for Promoting Skin Wound Healing Combined with Ionizing Radiation Injury.

Authors: Zaizhi Du; Han Liu; Xie Huang; Yang Li; Liting Wang; Jing Liu; Shuang Long; Rong Li; Qiang Xiang; Shenglin Luo
Journal: Pharmaceuticals (Basel) Date: 2022-06-06

5. A Case of Squamous Cell Carcinoma of the Nasal Cavity Treated With Total Rhinectomy.

Authors: Theresa A Schneider; Oscar Gryn; Matthew Lutz
Journal: Cureus Date: 2022-03-28

6. An expression analysis of markers of radiation-induced skin fibrosis and angiogenesis in wound healing disorders of the head and neck.

Authors: Steffen Koerdt; Nils H Rohleder; Niklas Rommel; Christopher Nobis; Mechthild Stoeckelhuber; Steffi Pigorsch; Marciana-Nona Duma; Klaus-Dietrich Wolff; Marco R Kesting
Journal: Radiat Oncol Date: 2015-09-22 Impact factor: 3.481