| Literature DB >> 15043437 |
Eric W Schmidt1, Carmen Raventos-Suarez, Marc Bifano, Ana T Menendez, Craig R Fairchild, D John Faulkner.
Abstract
The lithistid sponge Scleritoderma nodosum contains a new cyclic peptide, scleritodermin A (1), the structure of which incorporates l-proline, l-serine, and keto-allo-isoleucine units as well as a novel conjugated thiazole moiety (ACT) and O-methyl-N-sulfoserine. Scleritodermin A (1) inhibited tubulin polymerization and showed significant in vitro cytotoxicity against human tumor cell lines.Entities:
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Year: 2004 PMID： 15043437 DOI： 10.1021/np034035z
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050