| Literature DB >> 15043401 |
Gerhard Bringmann1, Gerhard Lang, Stefan Steffens, Karsten Schaumann.
Abstract
A strain of Penicillium brevicompactum derived from a specimen of the Mediterranean sponge Petrosia ficiformis was investigated for its secondary metabolites. Using fast centrifugal partitioning chromatography (FCPC) two previously unknown cyclodepsipeptides, petrosifungins A (1) and B (2), were isolated, both containing two neighboring units of the nonproteinogenic amino acid l-pipecolinic acid. The absolute configurations of all amino acids were established to be l using GITC derivatization and Marfey's method. Furthermore, the known metabolite brevianamide A (3) was isolated. The likewise known compounds mycophenolic acid (4) and asperphenamate (5) were identified from their spectroscopic properties directly in the extract using HPLC-UV, -MS, and -NMR coupling.Entities:
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Year: 2004 PMID： 15043401 DOI： 10.1021/np034015x
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050