OBJECTIVE: The arcus tendineous fasciae pelvis (ATFP) provides support to the anterior vagina. The objective of this study was to determine the impact of menopause on the structural components of the ATFP. STUDY DESIGN: Biopsy specimens of the ATFP were obtained from 10 premenopausal, 5 postmenopausal, and 12 postmenopausal women on hormone therapy. Scanning confocal microscopy of fluorescent micrographs was used to define the amount of collagen subtypes, smooth muscle, and elastin. Collagen fiber orientation was determined by scanning electron microscopy. RESULTS: The ATFP is comprised primarily of parallel bundles of type III collagen fibers (84%), an intermediate amount of elastin (13%), and very little smooth muscle. The ratio of collagen I/(III+V) was decreased in postmenopausal not on hormones relative to premenopausal women (P=.04) due to a 75% decrease in collagen I (P=.046). The decrease in collagen I and change in collagen ratios was not present in women on hormone therapy. Comparison of the amounts of elastin and smooth muscle showed no difference in the ATFP of premenopausal and postmenopausal women. CONCLUSION: Menopause in the absence of hormone therapy is associated with a decrease in quantity of collagen I in the ATFP resulting in a decrease in the ratio of collagen I/(III+V). This may compromise the tensile strength and an increase susceptibility to anterior vaginal wall prolapse.
OBJECTIVE: The arcus tendineous fasciae pelvis (ATFP) provides support to the anterior vagina. The objective of this study was to determine the impact of menopause on the structural components of the ATFP. STUDY DESIGN: Biopsy specimens of the ATFP were obtained from 10 premenopausal, 5 postmenopausal, and 12 postmenopausal women on hormone therapy. Scanning confocal microscopy of fluorescent micrographs was used to define the amount of collagen subtypes, smooth muscle, and elastin. Collagen fiber orientation was determined by scanning electron microscopy. RESULTS: The ATFP is comprised primarily of parallel bundles of type III collagen fibers (84%), an intermediate amount of elastin (13%), and very little smooth muscle. The ratio of collagen I/(III+V) was decreased in postmenopausal not on hormones relative to premenopausal women (P=.04) due to a 75% decrease in collagen I (P=.046). The decrease in collagen I and change in collagen ratios was not present in women on hormone therapy. Comparison of the amounts of elastin and smooth muscle showed no difference in the ATFP of premenopausal and postmenopausal women. CONCLUSION: Menopause in the absence of hormone therapy is associated with a decrease in quantity of collagen I in the ATFP resulting in a decrease in the ratio of collagen I/(III+V). This may compromise the tensile strength and an increase susceptibility to anterior vaginal wall prolapse.
Authors: Christina Lewicky-Gaupp; Aisha Yousuf; Kindra A Larson; Dee E Fenner; John O L Delancey Journal: Am J Obstet Gynecol Date: 2010-05 Impact factor: 8.661
Authors: Diaa E E Rizk; Mohamed A Fahim; Hazem A Hassan; Ahmed H Al-Marzouqi; Gaber A Ramadan; Soha S Al-Kedrah; Layla S Al-Ghafri Journal: Int Urogynecol J Pelvic Floor Dysfunct Date: 2007-01-05
Authors: Yvonne Hsu; Luyun Chen; Aimee Summers; James A Ashton-Miller; John O L DeLancey; James O L DeLancey Journal: Int Urogynecol J Pelvic Floor Dysfunct Date: 2007-06-20
Authors: Diaa E E Rizk; Hazem A Hassan; Ahmed H Al-Marzouqi; Gaber A Ramadan; Soha S Al-Kedrah; Sayel A Daoud; Mohamed A Fahim Journal: Int Urogynecol J Pelvic Floor Dysfunct Date: 2007-09-18
Authors: Cecilia K Wieslander; David D Rahn; Donald D McIntire; Jesús F Acevedo; Peter G Drewes; Hiromi Yanagisawa; R Ann Word Journal: Biol Reprod Date: 2008-11-05 Impact factor: 4.285