Literature DB >> 15039366

SKN7 of Candida albicans: mutant construction and phenotype analysis.

Praveen Singh1, Neeraj Chauhan, Anup Ghosh, Freddie Dixon, Richard Calderone.   

Abstract

The SKN7 two-component response regulator gene of Candida albicans was deleted, and the phenotype of the mutant was established. This mutant exhibited impaired growth on Spider agar and 10% serum agar compared to wild-type and gene-reconstituted strains. The skn7 mutant was sensitive to H(2)O(2) in vitro, but its virulence was only mildly attenuated. A comparison of the Skn7p and Ssk1p response regulators of C. albicans is discussed.

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Year:  2004        PMID： 15039366      PMCID： PMC375215          DOI： 10.1128/IAI.72.4.2390-2394.2004

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  46 in total

1.  Yap1 and Skn7 control two specialized oxidative stress response regulons in yeast.

Authors:  J Lee; C Godon; G Lagniel; D Spector; J Garin; J Labarre; M B Toledano
Journal:  J Biol Chem       Date:  1999-06-04       Impact factor: 5.157

Review 2.  Two-component signal transduction as a target for microbial anti-infective therapy.

Authors:  J F Barrett; J A Hoch
Journal:  Antimicrob Agents Chemother       Date:  1998-07       Impact factor: 5.191

3.  Acute neutropenia decreases inflammation associated with murine vaginal candidiasis but has no effect on the course of infection.

Authors:  C A Black; F M Eyers; A Russell; M L Dunkley; R L Clancy; K W Beagley
Journal:  Infect Immun       Date:  1998-03       Impact factor: 3.441

4.  The oxidative stress response mediated via Pos9/Skn7 is negatively regulated by the Ras/PKA pathway in Saccharomyces cerevisiae.

Authors:  C Charizanis; H Juhnke; B Krems; K D Entian
Journal:  Mol Gen Genet       Date:  1999-06

5.  Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the yeast response regulator protein Skn7.

Authors:  A S Alberts; N Bouquin; L H Johnston; R Treisman
Journal:  J Biol Chem       Date:  1998-04-10       Impact factor: 5.157

6.  Absence of respiratory burst in X-linked chronic granulomatous disease mice leads to abnormalities in both host defense and inflammatory response to Aspergillus fumigatus.

Authors:  D E Morgenstern; M A Gifford; L L Li; C M Doerschuk; M C Dinauer
Journal:  J Exp Med       Date:  1997-01-20       Impact factor: 14.307

7.  Regulators of pseudohyphal differentiation in Saccharomyces cerevisiae identified through multicopy suppressor analysis in ammonium permease mutant strains.

Authors:  M C Lorenz; J Heitman
Journal:  Genetics       Date:  1998-12       Impact factor: 4.562

8.  The two-component hybrid kinase regulator CaNIK1 of Candida albicans.

Authors:  Thyagarajan Srikantha; Luong Tsai; Karla Daniels; Lee Enger; Kumiko Highley; David R Soll
Journal:  Microbiology (Reading)       Date:  1998-10       Impact factor: 2.777

9.  COS1, a two-component histidine kinase that is involved in hyphal development in the opportunistic pathogen Candida albicans.

Authors:  L A Alex; C Korch; C P Selitrennikoff; M I Simon
Journal:  Proc Natl Acad Sci U S A       Date:  1998-06-09       Impact factor: 11.205

10.  Identification of a putative histidine kinase two-component phosphorelay gene (CaHK1) in Candida albicans.

Authors:  J A Calera; G H Choi; R A Calderone
Journal:  Yeast       Date:  1998-05       Impact factor: 3.239
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  47 in total

1.  Oxidative stress survival in a clinical Saccharomyces cerevisiae isolate is influenced by a major quantitative trait nucleotide.

Authors:  Stephanie Diezmann; Fred S Dietrich
Journal:  Genetics       Date:  2011-04-21       Impact factor: 4.562

Review 2.  Fungal Skn7 stress responses and their relationship to virulence.

Authors:  Jan S Fassler; Ann H West
Journal:  Eukaryot Cell       Date:  2010-12-03

3.  Two-component response regulators Ssk1p and Skn7p additively regulate high-osmolarity adaptation and fungicide sensitivity in Cochliobolus heterostrophus.

Authors:  Kosuke Izumitsu; Akira Yoshimi; Chihiro Tanaka
Journal:  Eukaryot Cell       Date:  2006-12-08

Review 4.  Master and commander in fungal pathogens: the two-component system and the HOG signaling pathway.

Authors:  Yong-Sun Bahn
Journal:  Eukaryot Cell       Date:  2008-10-24

5.  Unraveling the Function of the Response Regulator BcSkn7 in the Stress Signaling Network of Botrytis cinerea.

Authors:  Anne Viefhues; Ina Schlathoelter; Adeline Simon; Muriel Viaud; Paul Tudzynski
Journal:  Eukaryot Cell       Date:  2015-05-01

6.  Candida albicans SRR1, a putative two-component response regulator gene, is required for stress adaptation, morphogenesis, and virulence.

Authors:  Chirayu Desai; John Mavrianos; Neeraj Chauhan
Journal:  Eukaryot Cell       Date:  2011-08-12

7.  Penicillium marneffei SKN7, a novel gene, could complement the hypersensitivity of S. cerevisiae skn7 Disruptant strain to oxidative stress.

Authors:  Cunwei Cao; Wei Liu; Ruoyu Li
Journal:  Mycopathologia       Date:  2009-03-18       Impact factor: 2.574

8.  Mitochondrial two-component signaling systems in Candida albicans.

Authors:  John Mavrianos; Elizabeth L Berkow; Chirayu Desai; Alok Pandey; Mona Batish; Marissa J Rabadi; Katherine S Barker; Debkumar Pain; P David Rogers; Eliseo A Eugenin; Neeraj Chauhan
Journal:  Eukaryot Cell       Date:  2013-04-12

Review 9.  Nitrosative and oxidative stress responses in fungal pathogenicity.

Authors:  Alistair J P Brown; Ken Haynes; Janet Quinn
Journal:  Curr Opin Microbiol       Date:  2009-07-16       Impact factor: 7.934

10.  Global screening of potential Candida albicans biofilm-related transcription factors via network comparison.

Authors:  Yu-Chao Wang; Chung-Yu Lan; Wen-Ping Hsieh; Luis A Murillo; Nina Agabian; Bor-Sen Chen
Journal:  BMC Bioinformatics       Date:  2010-01-26       Impact factor: 3.169
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