Literature DB >> 21841121

Candida albicans SRR1, a putative two-component response regulator gene, is required for stress adaptation, morphogenesis, and virulence.

Chirayu Desai1, John Mavrianos, Neeraj Chauhan.   

Abstract

We report here the identification and characterization of a previously uncharacterized, two-component response regulator gene (orf19.5843) from Candida albicans. Because of its apparent functions in stress adaptation, we have named this gene SRR1 (stress response regulator 1). Disruption of SRR1 causes defects in hyphal development, reduced resistance to stress, and severe virulence attenuation in the mouse model of disseminated candidiasis.

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Year:  2011        PMID： 21841121      PMCID： PMC3187061          DOI： 10.1128/EC.05188-11

Source DB:  PubMed          Journal:  Eukaryot Cell        ISSN： 1535-9786


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