| Literature DB >> 15038335 |
Neal Slatkin1, Michelle Rhiner.
Abstract
A 55-year-old woman with advanced ovarian cancer and severe pain developed hypoactive delirium after an increase in her opioid dosage. Myoclonus and delirium improved dramatically with the intravenous injection of the acetylcholinesterase inhibitor physostigmine, and this improvement was maintained during the administration of donepezil, an oral medication with similar pharmacodynamic properties. Evidence for a disorder of cholinergic neurotransmission in opioid-induced delirium is discussed, as is the rationale for treatment with acetylcholinesterase inhibitors and other cholinomimetic agents.Entities:
Mesh：
Substances：
Year: 2004 PMID： 15038335 DOI： 10.1016/j.jpainsymman.2003.07.002
Source DB: PubMed Journal: J Pain Symptom Manage ISSN： 0885-3924 Impact factor: 3.612