| Literature DB >> 15037123 |
L B Avalle, Z Wang, J P Dillon, E R Gaillard.
Abstract
Several retinal dystrophies are associated with the accumulation of lipofuscin in the retinal pigment epithelium (RPE). The only structurally characterized component of human retinal lipofuscin is the bis-retinoid pyridinium compound A2E. We report here on the observation of a monooxygenated product of A2E in the organic soluble portion of human retinal lipofuscin and in the organic extract of bovine RPE cells that have been fed A2E and irradiated. Liquid chromatography mass spectrometry confirms that the products are identical. This is the first observation of a photoproduct of A2E in human retinal lipofuscin.Entities:
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Year: 2004 PMID： 15037123 DOI： 10.1016/j.exer.2003.10.023
Source DB: PubMed Journal: Exp Eye Res ISSN： 0014-4835 Impact factor: 3.467