Literature DB >> 15036863

Chemoenzymatic dynamic kinetic resolution.

Oscar Pàmies1, Jan-E Bäckvall.   

Abstract

During the past decade a new concept has appeared in asymmetric catalysis involving the combination of a biocatalyst and a chemocatalyst in one 'pot' leading to efficient deracemization via dynamic kinetic resolution (DKR). Here, we outline the different strategies that have been developed for efficient chemoenzymatic DKR, in particular the powerful combination of an enzyme and a metal catalyst.

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Year:  2004        PMID: 15036863     DOI: 10.1016/j.tibtech.2004.01.005

Source DB:  PubMed          Journal:  Trends Biotechnol        ISSN: 0167-7799            Impact factor:   19.536


  4 in total

1.  Single-operation deracemization of 3H-indolines and tetrahydroquinolines enabled by phase separation.

Authors:  Aaron D Lackner; Andrew V Samant; F Dean Toste
Journal:  J Am Chem Soc       Date:  2013-09-11       Impact factor: 15.419

2.  Combinatorial library based engineering of Candida antarctica lipase A for enantioselective transacylation of sec-alcohols in organic solvent.

Authors:  Ylva Wikmark; Maria Svedendahl Humble; Jan-E Bäckvall
Journal:  Angew Chem Int Ed Engl       Date:  2015-02-09       Impact factor: 15.336

3.  Deracemization of 1-phenylethanols in a one-pot process combining Mn-driven oxidation with enzymatic reduction utilizing a compartmentalization technique.

Authors:  Hirofumi Sato; Rei Yamada; Yomi Watanabe; Takaaki Kiryu; Shintaro Kawano; Motohiro Shizuma; Hideya Kawasaki
Journal:  RSC Adv       Date:  2022-04-06       Impact factor: 3.361

4.  Efficient asymmetric synthesis of 1-cyano-tetrahydroisoquinolines from lipase dual activity and opposite enantioselectivities in α-Aminonitrile resolution.

Authors:  Morakot Sakulsombat; Pornrapee Vongvilai; Olof Ramström
Journal:  Chemistry       Date:  2014-07-23       Impact factor: 5.236

  4 in total

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