Literature DB >> 1503545

Analysis of relative mRNA levels and protein patterns in brains of rat strains bred for differing levels of emotionality.

S A Whatley1, C W Perrett, R Zamani, J A Gray.   

Abstract

mRNA and protein populations were studied in the brains of Maudsley reactive (MR) and Maudsley nonreactive (MNR) rat strains, which exhibit differing levels of emotionality. Translational analysis of forebrain mRNA indicated that the relative levels of two translation products (42 kDA, pI 5.0; 30 kDa, pI 5.8) were increased in the MR compared to the MNR strain. In addition, a charge-shift variant of a 36 kDa protein was present in the MR strain. Analysis of brain protein patterns indicated that a protein of 39 kDa, pI 5.0, was found to be more abundant in MR compared with MNR strains in both frontal cortex and hippocampus and the relative level of one protein (40 kDa, pI 5.8) was decreased in the frontal cortex.

Entities:  

Mesh：

Substances：

Year:  1992        PMID： 1503545     DOI： 10.1007/bf01066612

Source DB:  PubMed          Journal:  Behav Genet        ISSN： 0001-8244            Impact factor:   2.805


  12 in total

1.  An estimation of the sensitivity of in vitro translation using two-dimensional gel analysis.

Authors:  C W Perrett; S A Whatley
Journal:  Electrophoresis       Date:  1991 Jul-Aug       Impact factor: 3.535

2.  The Maudsley reactive and nonreactive strains of rats: a survey.

Authors:  P L Broadhurst
Journal:  Behav Genet       Date:  1975-10       Impact factor: 2.805

3.  Radioiodination of proteins in single polyacrylamide gel slices. Tryptic peptide analysis of all the major members of complex multicomponent systems using microgram quantities of total protein.

Authors:  J H Elder; R A Pickett; J Hampton; R A Lerner
Journal:  J Biol Chem       Date:  1977-09-25       Impact factor: 5.157

4.  High resolution two-dimensional electrophoresis of proteins.

Authors:  P H O'Farrell
Journal:  J Biol Chem       Date:  1975-05-25       Impact factor: 5.157

5.  Lack of functional messenger RNA (mRNA) coding for a microtubule-associated protein correlates with poor performance of rats in a behavioral paradigm.

Authors:  P Strocchi; G S Zubenko; J M Gilbert
Journal:  Behav Genet       Date:  1983-09       Impact factor: 2.805

6.  Alterations in the relative amounts of specific mRNA species in the developing human brain in Down's syndrome.

Authors:  S A Whatley; C Hall; A N Davison; L Lim
Journal:  Biochem J       Date:  1984-05-15       Impact factor: 3.857

7.  Hereditary covariations of neuronal circuitry and behavior: correlations between the proportions of hippocampal synaptic fields in the regio inferior and two-way avoidance in mice and rats.

Authors:  H Schwegler; H P Lipp
Journal:  Behav Brain Res       Date:  1983-01       Impact factor: 3.332

8.  The Maudsley reactive and nonreactive strains: a North American perspective.

Authors:  D A Blizard
Journal:  Behav Genet       Date:  1981-09       Impact factor: 2.805

9.  Emotionality in male and female rodents: a reply to Archer.

Authors:  J A Gray
Journal:  Br J Psychol       Date:  1979-08

10.  Rapid corticosterone-induced changes in gene expression in rat hippocampus display type II glucocorticoid receptor specificity.

Authors:  N R Nichols; S P Lerner; J N Masters; P C May; S L Millar; C E Finch
Journal:  Mol Endocrinol       Date:  1988-03
View more
  2 in total

Review 1.  Transgenic animals as models for human disease--report of an EC Study Group.

Authors:  R Lathe; J J Mullins
Journal:  Transgenic Res       Date:  1993-09       Impact factor: 2.788

Review 2.  Modeling heritability of temperamental differences, stress reactivity, and risk for anxiety and depression: Relevance to research domain criteria (RDoC).

Authors:  Sarah M Clinton; Elizabeth A Shupe; Matthew E Glover; Keaton A Unroe; Chelsea R McCoy; Joshua L Cohen; Ilan A Kerman
Journal:  Eur J Neurosci       Date:  2021-03-24       Impact factor: 3.698
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.