| Literature DB >> 150334 |
S K Bhattacharya, P R Keshary, A K Sanyal.
Abstract
Immobilisation of rats for 1, 2 and 4 h induced duration-related antinociception. Antinociception induced by 4 h immobilisation was significantly inhibited after pretreatment by drugs known to inhibit synthesis of serotonin, induce degeneration of serotonergic neurones and inhibit prostaglandin synthesis. The results indicate that immobilisation stress induces autoanalgesia, which may be dependent on the availability of endogenous serotonin and prostaglandins in rat brain.Entities:
Mesh:
Substances:
Year: 1978 PMID: 150334 DOI: 10.1016/0014-2999(78)90257-1
Source DB: PubMed Journal: Eur J Pharmacol ISSN: 0014-2999 Impact factor: 4.432