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Literature DB >> 15031715

Potent inhibitors of anthrax lethal factor from green tea.

Isabella Dell'Aica¹, Massimo Donà, Fiorella Tonello, Alejandro Piris, Michèle Mock, Cesare Montecucco, Spiridione Garbisa.

Abstract

The anthrax lethal factor (LF) has a major role in the development of anthrax. LF is delivered by the protective antigen (PA) inside the cell, where it exerts its metalloprotease activity on the N-terminus of MAPK-kinases. PA+LF are cytotoxic to macrophages in culture and kill the Fischer 344 rat when injected intravenously. We describe here the properties of some polyphenols contained in green tea as powerful inhibitors of LF metalloproteolytic activity, and how the main catechin of green tea, (-)epigallocatechin-3-gallate, prevents the LF-induced death of macrophages and Fischer 344 rats.

Entities: Chemical Disease Species

Mesh：

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Year: 2004 PMID： 15031715 PMCID： PMC1299029 DOI： 10.1038/sj.embor.7400118

Source DB: PubMed Journal: EMBO Rep ISSN： 1469-221X Impact factor: 8.807

29 in total

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Journal: Nat Med Date: 1999-11 Impact factor: 53.440

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Journal: Nature Date: 2001-11-08 Impact factor: 49.962

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Authors: S Garbisa; L Sartor; S Biggin; B Salvato; R Benelli; A Albini
Journal: Cancer Date: 2001-02-15 Impact factor: 6.860

4. Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor.

Authors: G Vitale; L Bernardi; G Napolitani; M Mock; C Montecucco
Journal: Biochem J Date: 2000-12-15 Impact factor: 3.857

5. Anthrax lethal factor cleaves MKK3 in macrophages and inhibits the LPS/IFNgamma-induced release of NO and TNFalpha.

Authors: R Pellizzari; C Guidi-Rontani; G Vitale; M Mock; C Montecucco
Journal: FEBS Lett Date: 1999-11-26 Impact factor: 4.124

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Authors: M Maeda-Yamamoto; H Kawahara; N Tahara; K Tsuji; Y Hara; M Isemura
Journal: J Agric Food Chem Date: 1999-06 Impact factor: 5.279

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Authors: M Demeule; M Brossard; M Pagé; D Gingras; R Béliveau
Journal: Biochim Biophys Acta Date: 2000-03-16

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Authors: D B Lacy; R J Collier
Journal: Curr Top Microbiol Immunol Date: 2002 Impact factor: 4.291

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Authors: Jin Mo Park; Florian R Greten; Zhi-Wei Li; Michael Karin
Journal: Science Date: 2002-08-29 Impact factor: 47.728

10. Screening inhibitors of anthrax lethal factor.

Authors: Fiorella Tonello; Michela Seveso; Oriano Marin; Michèle Mock; Cesare Montecucco
Journal: Nature Date: 2002-07-25 Impact factor: 49.962

25 in total

Review 1. Targeting Metalloenzymes for Therapeutic Intervention.

Authors: Allie Y Chen; Rebecca N Adamek; Benjamin L Dick; Cy V Credille; Christine N Morrison; Seth M Cohen
Journal: Chem Rev Date: 2018-09-07 Impact factor: 60.622

Review 2. New developments in vaccines, inhibitors of anthrax toxins, and antibiotic therapeutics for Bacillus anthracis.

Authors: J M Beierlein; A C Anderson
Journal: Curr Med Chem Date: 2011 Impact factor: 4.530

Review 3. An overview of investigational toxin-directed therapies for the adjunctive management of Bacillus anthracis infection and sepsis.

Authors: Lernik Ohanjanian; Kenneth E Remy; Yan Li; Xizhong Cui; Peter Q Eichacker
Journal: Expert Opin Investig Drugs Date: 2015-04-28 Impact factor: 6.206

4. Identification of exosite-targeting inhibitors of anthrax lethal factor by high-throughput screening.

Authors: Ludovic Bannwarth; Allison B Goldberg; Catherine Chen; Benjamin E Turk
Journal: Chem Biol Date: 2012-07-27

5. Highly predictive support vector machine (SVM) models for anthrax toxin lethal factor (LF) inhibitors.

Authors: Xia Zhang; Elizabeth Ambrose Amin
Journal: J Mol Graph Model Date: 2015-11-17 Impact factor: 2.518

6. Small molecule inhibitors of anthrax lethal factor toxin.

Authors: John D Williams; Atiyya R Khan; Steven C Cardinale; Michelle M Butler; Terry L Bowlin; Norton P Peet
Journal: Bioorg Med Chem Date: 2013-11-13 Impact factor: 3.641

7. Identification of novel non-hydroxamate anthrax toxin lethal factor inhibitors by topomeric searching, docking and scoring, and in vitro screening.

Authors: Ting-Lan Chiu; Jonathan Solberg; Satish Patil; Todd W Geders; Xia Zhang; Subhashree Rangarajan; Rawle Francis; Barry C Finzel; Michael A Walters; Derek J Hook; Elizabeth A Amin
Journal: J Chem Inf Model Date: 2009-12 Impact factor: 4.956

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Authors: Jeremy Mogridge
Journal: Drug Discov Today Dis Mech Date: 2007

9. Small-molecule inhibitors of lethal factor protease activity protect against anthrax infection.

Authors: Mahtab Moayeri; Devorah Crown; Guan-Sheng Jiao; Seongjin Kim; Alan Johnson; Clinton Leysath; Stephen H Leppla
Journal: Antimicrob Agents Chemother Date: 2013-06-17 Impact factor: 5.191

10. Use of a recombinant fluorescent substrate with cleavage sites for all botulinum neurotoxins in high-throughput screening of natural product extracts for inhibitors of serotypes A, B, and E.

Authors: Harry B Hines; Alexander D Kim; Robert G Stafford; Shirin S Badie; Ernst E Brueggeman; David J Newman; James J Schmidt
Journal: Appl Environ Microbiol Date: 2007-12-14 Impact factor: 4.792