PURPOSE: To investigate the use of magnetic resonance (MR) imaging in the administration and biodistribution of holmium-loaded poly(L-lactic acid) microspheres (Ho-PLLA-MS) in liver tumors. MATERIALS AND METHODS: MR imaging measurements were obtained in phantoms, three ex vivo rabbit livers, and four livers in living rabbits. When applicable, measurements were compared with those on scintigraphic images. The transverse relaxivity R2* of the Ho-PLLA-MS was determined in a phantom study. The in vivo animal experiments were performed by using rabbits with an implanted VX2 tumor. Detection of passing Ho-PLLA-MS to estimate lung shunting was performed in a scaled model of the vena cava. RESULTS: In the ex vivo liver experiments, the feasibility of real-time MR imaging during administration of microspheres was demonstrated. The in vivo rabbit experiments demonstrated that MR imaging can depict radioactive, nonradioactive, and decayed Ho-PLLA-MS after treatment for as long as they remain in the body. Furthermore, this study showed the ability of dynamic MR imaging to detect single doses of passing Ho-PLLA-MS. CONCLUSION: Ho-PLLA-MS used for internal radionuclide therapy can be imaged clearly in vivo with MR imaging.
PURPOSE: To investigate the use of magnetic resonance (MR) imaging in the administration and biodistribution of holmium-loaded poly(L-lactic acid) microspheres (Ho-PLLA-MS) in liver tumors. MATERIALS AND METHODS: MR imaging measurements were obtained in phantoms, three ex vivo rabbit livers, and four livers in living rabbits. When applicable, measurements were compared with those on scintigraphic images. The transverse relaxivity R2* of the Ho-PLLA-MS was determined in a phantom study. The in vivo animal experiments were performed by using rabbits with an implanted VX2 tumor. Detection of passing Ho-PLLA-MS to estimate lung shunting was performed in a scaled model of the vena cava. RESULTS: In the ex vivo liver experiments, the feasibility of real-time MR imaging during administration of microspheres was demonstrated. The in vivo rabbit experiments demonstrated that MR imaging can depict radioactive, nonradioactive, and decayed Ho-PLLA-MS after treatment for as long as they remain in the body. Furthermore, this study showed the ability of dynamic MR imaging to detect single doses of passing Ho-PLLA-MS. CONCLUSION: Ho-PLLA-MS used for internal radionuclide therapy can be imaged clearly in vivo with MR imaging.
Authors: Aaron C Eifler; Robert J Lewandowski; Sumeet Virmani; Johnathan C Chung; Dingxin Wang; Richard L Tang; Barbara Szolc-Kowalska; Gayle E Woloschak; Guang-Yu Yang; Robert K Ryu; Riad Salem; Andrew C Larson; Eric Cheon; Matthew Strouch; David J Bentrem; Reed A Omary Journal: J Vasc Interv Radiol Date: 2009-06-28 Impact factor: 3.464
Authors: Maarten L J Smits; Johannes F W Nijsen; Maurice A A J van den Bosch; Marnix G E H Lam; Maarten A D Vente; Julia E Huijbregts; Alfred D van het Schip; Mattijs Elschot; Wouter Bult; Hugo W A M de Jong; Pieter C W Meulenhoff; Bernard A Zonnenberg Journal: J Exp Clin Cancer Res Date: 2010-06-15
Authors: Twinkle Gupta; Sumeet Virmani; Tod M Neidt; Barbara Szolc-Kowalska; Kent T Sato; Robert K Ryu; Robert J Lewandowski; Vanessa L Gates; Gayle E Woloschak; Riad Salem; Reed A Omary; Andrew C Larson Journal: Radiology Date: 2008-10-07 Impact factor: 11.105
Authors: W Bult; P R Seevinck; G C Krijger; T Visser; L M J Kroon-Batenburg; C J G Bakker; W E Hennink; A D van het Schip; J F W Nijsen Journal: Pharm Res Date: 2009-02-25 Impact factor: 4.200
Authors: M A D Vente; J F W Nijsen; R de Roos; M J van Steenbergen; C N J Kaaijk; M J J Koster-Ammerlaan; P F A de Leege; W E Hennink; A D van Het Schip; G C Krijger Journal: Biomed Microdevices Date: 2009-08 Impact factor: 2.838
Authors: Mattijs Elschot; Johannes Franciscus Wilhelmus Nijsen; Alida Johanna Dam; Hugo Wilhelmus Antonius Maria de Jong Journal: PLoS One Date: 2011-11-03 Impact factor: 3.240
Authors: M A D Vente; T C de Wit; M A A J van den Bosch; W Bult; P R Seevinck; B A Zonnenberg; H W A M de Jong; G C Krijger; C J G Bakker; A D van het Schip; J F W Nijsen Journal: Eur Radiol Date: 2009-09-30 Impact factor: 5.315
Authors: M A D Vente; J F W Nijsen; T C de Wit; J H Seppenwoolde; G C Krijger; P R Seevinck; A Huisman; B A Zonnenberg; T S G A M van den Ingh; A D van het Schip Journal: Eur J Nucl Med Mol Imaging Date: 2008-03-11 Impact factor: 9.236