| Literature DB >> 15026168 |
Lynnette J Cook1, Luk W Ho, Alison E Taylor, Carol Brayne, John Grimley Evans, John Xuereb, Nigel J Cairns, Antonia Pritchard, Helen Lemmon, David Mann, David St Clair, Dragana Turic, Paul Hollingworth, Pamela J Moore, Luke Jehu, Nicola Archer, Sarah Walter, Catherine Foy, Amanda Edmondson, John Powell, Simon Lovestone, Michael J Owen, Julie Williams, Corinne Lendon, David C Rubinsztein.
Abstract
Consistent deficits in the cholinergic system are evident in Alzheimer's disease (AD) patients, including selective loss of alpha4beta2 nicotinic acetylcholine receptors in the brains of AD patients. Knockout mice for the beta2 subunit have impaired neuronal survival in ageing. Accordingly, we have analysed polymorphisms in the genes that encode the alpha4 and beta2 subunits, CHRNA4 and CHRNB2 respectively, for genetic associations with late-onset AD. A significant association for disease was observed for a non-coding polymorphism in CHRNB2 (odds ratio=0.57, 95% confidence interval=0.35-0.95, P=0.024). Replication analysis was performed in two further sample sets. While these did not individually yield significant results, a significant association remained when all samples were pooled (odds ratio=0.70, 95% confidence interval=0.52-0.95, P=0.019). These data suggest that this variant warrants further examination in large case-control series.Entities:
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Year: 2004 PMID： 15026168 DOI： 10.1016/j.neulet.2004.01.016
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046