| Literature DB >> 15025470 |
Gijsbert M Grotenbreg1, Mattie S M Timmer, Antonio L Llamas-Saiz, Martijn Verdoes, Gijsbert A van der Marel, Mark J van Raaij, Herman S Overkleeft, Mark Overhand.
Abstract
A new reverse turn, replacing one of the native type II' beta-turns in the cyclic peptide antibiotic gramicidin S, induced by a furanoid sugar amino acid is revealed. The C3-hydroxyl function plays a pivotal role by acting as a H-bond acceptor, consequently flipping the amide bond between residues i and i + 1, as was established by NMR and X-ray crystallographic analysis.Entities:
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Year: 2004 PMID： 15025470 DOI： 10.1021/ja0397254
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419