Literature DB >> 15025149

Clinical evaluation of a powder of quality elk velvet antler for the treatment of osteoarthrosis in dogs.

Maxim Moreau1, Jacques Dupuis, Norbert H Bonneau, Manon Lécuyer.   

Abstract

A powder of quality elk velvet antler (QEVA) was evaluated on client-owned dogs with osteoarthrosis (OA) in a clinical, double-blind, and placebo-controlled study. Thirteen dogs received a placebo for 30 days and then QEVA for 60 days. Twenty-five other dogs received QEVA for 60 days. Gait analysis measured with a force plate, clinical signs assessed by an orthopedic surgeon, performances in daily life activities and vitality assessed by the owners, and complete blood analyses were obtained at days 0, after 30 days of placebo and/or 60 days of QEVA. On placebo, the 13 dogs did not show significant improvement (P < 0.05); however, their gait, their performances in daily life activities, and their vitality were significantly improved on QEVA, based on changes in values exceeding those observed when placebo was administered. The 25 dogs on QEVA for 60 days showed similar improvements. No clinical changes were revealed on blood analyses. Administration of QEVA was effective in alleviating the condition in arthritic dogs.

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Year:  2004        PMID: 15025149      PMCID: PMC548602     

Source DB:  PubMed          Journal:  Can Vet J        ISSN: 0008-5286            Impact factor:   1.008


  24 in total

Review 1.  The role of the chondrocyte in osteoarthritis.

Authors:  M B Goldring
Journal:  Arthritis Rheum       Date:  2000-09

2.  Effects of diclofenac, aceclofenac and meloxicam on the metabolism of proteoglycans and hyaluronan in osteoarthritic human cartilage.

Authors:  L Blot; A Marcelis; J P Devogelaer; D H Manicourt
Journal:  Br J Pharmacol       Date:  2000-12       Impact factor: 8.739

Review 3.  The role of cytokines as inflammatory mediators in osteoarthritis: lessons from animal models.

Authors:  M B Goldring
Journal:  Connect Tissue Res       Date:  1999       Impact factor: 3.417

Review 4.  Biochemical basis of the pharmacologic action of chondroitin sulfates on the osteoarticular system.

Authors:  J P Bali; H Cousse; E Neuzil
Journal:  Semin Arthritis Rheum       Date:  2001-08       Impact factor: 5.532

Review 5.  Cytokines and their role in the pathophysiology of osteoarthritis.

Authors:  J Martel-Pelletier; N Alaaeddine; J P Pelletier
Journal:  Front Biosci       Date:  1999-10-15

6.  Carprofen simultaneously reduces progression of morphological changes in cartilage and subchondral bone in experimental dog osteoarthritis.

Authors:  J P Pelletier; D Lajeunesse; D V Jovanovic; V Lascau-Coman; F C Jolicoeur; G Hilal; J C Fernandes; J Martel-Pelletier
Journal:  J Rheumatol       Date:  2000-12       Impact factor: 4.666

7.  Effects of an orally administered mixture of chondroitin sulfate, glucosamine hydrochloride and manganese ascorbate on synovial fluid chondroitin sulfate 3B3 and 7D4 epitope in a canine cruciate ligament transection model of osteoarthritis.

Authors:  K A Johnson; D A Hulse; R C Hart; D Kochevar; Q Chu
Journal:  Osteoarthritis Cartilage       Date:  2001-01       Impact factor: 6.576

8.  Isolation, characterization and localization of glycosaminoglycans in growing antlers of wapiti (Cervus elaphus).

Authors:  H H Sunwoo; T Nakano; R J Hudson; J S Sim
Journal:  Comp Biochem Physiol B Biochem Mol Biol       Date:  1998-06       Impact factor: 2.231

9.  Efficacy of etodolac for the treatment of osteoarthritis of the hip joints in dogs.

Authors:  S C Budsberg; S A Johnston; P D Schwarz; C E DeCamp; R Claxton
Journal:  J Am Vet Med Assoc       Date:  1999-01-15       Impact factor: 1.936

Review 10.  Kinetic and kinematic gait analysis and the assessment of lameness in the dog.

Authors:  C E DeCamp
Journal:  Vet Clin North Am Small Anim Pract       Date:  1997-07       Impact factor: 2.093

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  13 in total

1.  Development and psychometric testing of an instrument designed to measure chronic pain in dogs with osteoarthritis.

Authors:  Dorothy Cimino Brown; Raymond C Boston; James C Coyne; John T Farrar
Journal:  Am J Vet Res       Date:  2007-06       Impact factor: 1.156

2.  Effect of a diet enriched with green-lipped mussel on pain behavior and functioning in dogs with clinical osteoarthritis.

Authors:  Pascale Rialland; Sylvain Bichot; Bertrand Lussier; Maxim Moreau; Francis Beaudry; Jérôme R E del Castillo; Dominique Gauvin; Eric Troncy
Journal:  Can J Vet Res       Date:  2013-01       Impact factor: 1.310

3.  Use of an activity monitor to detect response to treatment in dogs with osteoarthritis.

Authors:  Dorothy Cimino Brown; Raymond C Boston; John T Farrar
Journal:  J Am Vet Med Assoc       Date:  2010-07-01       Impact factor: 1.936

4.  Ability of the canine brief pain inventory to detect response to treatment in dogs with osteoarthritis.

Authors:  Dorothy Cimino Brown; Raymond C Boston; James C Coyne; John T Farrar
Journal:  J Am Vet Med Assoc       Date:  2008-10-15       Impact factor: 1.936

5.  Identification of potential therapeutic targets of deer antler extract on bone regulation based on serum proteomic analysis.

Authors:  Baojin Yao; Hongwei Gao; Jia Liu; Mei Zhang; Xiangyang Leng; Daqing Zhao
Journal:  Mol Biol Rep       Date:  2019-07-08       Impact factor: 2.316

6.  Vertebrates used for medicinal purposes by members of the Nyishi and Galo tribes in Arunachal Pradesh (North-East India).

Authors:  Jharna Chakravorty; V Benno Meyer-Rochow; Sampat Ghosh
Journal:  J Ethnobiol Ethnomed       Date:  2011-03-31       Impact factor: 2.733

7.  Dietary supplementation of female rats with elk velvet antler improves physical and neurological development of offspring.

Authors:  Jiongran Chen; Murray R Woodbury; Jane Alcorn; Ali Honaramooz
Journal:  Evid Based Complement Alternat Med       Date:  2012-04-03       Impact factor: 2.629

8.  Effect of Deer Antler Extract on Muscle Differentiation and 5-Aminoimidazole-4-Carboxamide Ribonucleoside (AICAR)-Induced Muscle Atrophy in C2C12 Cells.

Authors:  Kyungae Jo; Woo Young Jang; Beom Sik Yun; Jin Soo Kim; Hyun-Sun Lee; Yeok Boo Chang; Hyung Joo Suh
Journal:  Food Sci Anim Resour       Date:  2021-07-01

9.  Brachystemma calycinum D. Don Effectively Reduces the Locomotor Disability in Dogs with Naturally Occurring Osteoarthritis: A Randomized Placebo-Controlled Trial.

Authors:  Maxim Moreau; Bertrand Lussier; Jean-Pierre Pelletier; Johanne Martel-Pelletier; Christian Bédard; Dominique Gauvin; Eric Troncy
Journal:  Evid Based Complement Alternat Med       Date:  2012-07-15       Impact factor: 2.629

10.  A posteriori comparison of natural and surgical destabilization models of canine osteoarthritis.

Authors:  Maxim Moreau; Jean-Pierre Pelletier; Bertrand Lussier; Marc-André d'Anjou; Laurent Blond; Johanne-Martel Pelletier; Jérôme R E del Castillo; Eric Troncy
Journal:  Biomed Res Int       Date:  2013-10-31       Impact factor: 3.411

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